A Comparative Study of Recent Assays for the Determin8tion of Serum L-Cystine-aminopeptidase(CAP)

The authors describe a simplified and rapid method for determining L-cystineaminopeptidase ( CAP) in serum with the aid of S-benzyl-L-cysteine-p-nitroanilide (BCN). The liberated p-nitroaniline reacts with p-dimethylaminocinnamaldehyde to give ared dye. The method requires 15min incubation at 37°, f...

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Bibliographic Details
Published inJapanese Journal of Clinical Chemistry Vol. 5; no. 1; pp. 83 - 90
Main Authors KONNO, MINORU, HABA, SHOZO
Format Journal Article
LanguageJapanese
Published Japan Society of Clinical Chemistry 1976
一般社団法人 日本臨床化学会
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ISSN0370-5633
2187-4077
DOI10.14921/jscc1971b.5.1_83

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Summary:The authors describe a simplified and rapid method for determining L-cystineaminopeptidase ( CAP) in serum with the aid of S-benzyl-L-cysteine-p-nitroanilide (BCN). The liberated p-nitroaniline reacts with p-dimethylaminocinnamaldehyde to give ared dye. The method requires 15min incubation at 37°, followed by 10min colour development. The proposed method is more sensitive than that with using L-cystine-di-P-nitroaniiinde (CDNl) and using L-cystine-di-naphthylamide (Wada's method). The correlation coefficient between results of this method and those obtained with L-cystine-di-naphthylamide (CDNA) as substrate was 0.97.
ISSN:0370-5633
2187-4077
DOI:10.14921/jscc1971b.5.1_83