Study on the Efficacy of Azapropazone-A New Nonsteroidal Antiinf lammatory Drug-in Various Forms of Renal Diseases

• Published in: The Japanese Journal of Nephrology Vol. 19; no. 6; pp. 421 - 440
• Main Authors: OGUMA, Shigeru, MITSUNAMI, Kenichi, FUKADA, Junichi, TOMIMOTO, Ichihiko, TANAKA, Kazushige, KABURAGI, Tsuneo, HOSHINO, Tateo, IKEDA, Fumitake, SHINDO, Toshihiko, YOKOYAMA, Shoichi, TAKAYAMA, Shoichi, HANYU, Ikuhisa, SUZUKI, Toyosaka, HATTORI, Toshio
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Nephrology 1977
• ISSN: 0385-2385; 1884-0728
• DOI: 10.14842/jpnjnephrol1959.19.421

We tried to use a new nonsteroidal antiinflammatory drug "Azapropazone" (Cinnamin(R)) for 35 cases of various forms of renal diseases (chronic glomerulonephritis, nephrotic syndrome, chronic pyelonephritis and Alport syndrome). As a result of this new treatment, "Azapropazone" was ef-fective in 91.4 % for albuminuria and was in 38.2 % for hematuria which indomethacin was noneffective. Also, "Azapropazone" was effective in 6 cases among 7 cases for albuminuria of nephrotic syndrome which was non-effective on the steroid therapy. Consequently, hypoalbuminemia and hypercholesterolemia restored to normal value. And for hematuria of this group, "Azapropazone" was effective in 4 cases among 6 cases. However, after discontinuance of administrtion, albuminuria and hematuria became again to positive. Renal function during administration of "Azapropazone" showed increase, no change or decrease by case and by dosis. Decreased renal function restored after discontinuance of drug. Therefore, during administration of "Azapropazone" for renal diseases, Blood urea nitrogen, serum creatinine, serum potassium and renal function must be checked, necessarily. As side effect, exanthen and epigastrial discomfort were found in a few cases, but liver function damage and gastroduodenal ulcer that are caused by indomethacin, were not found.