Heat shock protein may be an immune target in the host's antitumor resistance

We identified transfomation-associated cell surface antigens (TAAs) that are expressed on a W31 H-rasoncogene trasformant of WFB rat fibroblast. One of TAAs, defined by mAb067, showed the enhanced expression by physicochemical stressors, and was supposed to be 70 heat shock cognate protein (hsc) its...

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Bibliographic Details
Published inEnsho Vol. 13; no. 5; pp. 465 - 470
Main Authors Sato, Noriyuki, Tamura, Yasuaki
Format Journal Article
LanguageJapanese
Published The Japanese Society of Inflammation and Regeneration 30.09.1993
Subjects
double negative T cells
heat shock protein
tumor antigen
tumor immunity
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ISSN0389-4290
1884-4006
DOI10.2492/jsir1981.13.465

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Summary:We identified transfomation-associated cell surface antigens (TAAs) that are expressed on a W31 H-rasoncogene trasformant of WFB rat fibroblast. One of TAAs, defined by mAb067, showed the enhanced expression by physicochemical stressors, and was supposed to be 70 heat shock cognate protein (hsc) itself. It was also shown that this antigen may be a target for CD4-CD8- double negative T cell (DNT), since mAb067 completely blocks the cytotoxicity of DNT against W31. These data strongly suggest that 70 hsc is a tumor antigen, and is a potential target for the host's tumor immunity. The capability of antigenic peptide presentation of 70 hsc was discussed.
ISSN:0389-4290
1884-4006
DOI:10.2492/jsir1981.13.465