A Review of the Prevention of Joint Destruction by the Biologics
Objectives: To review the prevention of joint destruction by the biologic agent, Inflixmab .To review the prevention of joint destruction at the knee joint, which is a large weiht-bearing joint, and in both hands, which represent a small affected joint. Methods: We evaluated 33 X ray images of both...
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| Published in | Japanese Journal of Joint Diseases Vol. 27; no. 1; pp. 25 - 30 |
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| Main Author | |
| Format | Journal Article |
| Language | English Japanese |
| Published |
Japanese Society for Joint Diseases
30.04.2008
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1883-2873 1884-9067 |
| DOI | 10.11551/jsjd2008.27.25 |
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| Abstract | Objectives: To review the prevention of joint destruction by the biologic agent, Inflixmab .To review the prevention of joint destruction at the knee joint, which is a large weiht-bearing joint, and in both hands, which represent a small affected joint. Methods: We evaluated 33 X ray images of both hands of tamed over more than 2 years according to the modified Sharps score Genant: Moreover, we evaluated A-P X ray image 31 knee joints from 19 subjects according to the Larsen grade. Results: In the evaluation by the modified Sharp score, the bone erosion scores improved from 0 to -0.21 and improvement was sustained 1 year up to 2 years later. The total score improved from 0 to -0.210.17 and improvement was sustained for 1 year up to 2 years. The joint narrowing score was aggravated from 0 to + 0.04 and improvement was sustained for 1 year up to 2 years later. In the evaluation by the Larsen grade, only 2 knees became aggravated. There were some cases in which the bone erosion improved. Conclusion: The prevention of joint destruction by the biologics (Infliximab) was evident in the knee joint, which is a large whight-bearing joint. |
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| AbstractList | Objectives: To review the prevention of joint destruction by the biologic agent, Inflixmab .To review the prevention of joint destruction at the knee joint, which is a large weiht-bearing joint, and in both hands, which represent a small affected joint. Methods: We evaluated 33 X ray images of both hands of tamed over more than 2 years according to the modified Sharps score Genant: Moreover, we evaluated A-P X ray image 31 knee joints from 19 subjects according to the Larsen grade. Results: In the evaluation by the modified Sharp score, the bone erosion scores improved from 0 to -0.21 and improvement was sustained 1 year up to 2 years later. The total score improved from 0 to -0.210.17 and improvement was sustained for 1 year up to 2 years. The joint narrowing score was aggravated from 0 to + 0.04 and improvement was sustained for 1 year up to 2 years later. In the evaluation by the Larsen grade, only 2 knees became aggravated. There were some cases in which the bone erosion improved. Conclusion: The prevention of joint destruction by the biologics (Infliximab) was evident in the knee joint, which is a large whight-bearing joint. |
| Author | SAKURAI, Takeo |
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| DOI | 10.11551/jsjd2008.27.25 |
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| References | 3) Lipsky, P. E., van der Heijde, M. F. M., et al.: Infliximab and methotrexate in the Treatment of rheumatoid arthritis. N Engl. J. Med., 30: 1594-1602, 2000. 4) Quinn, M. A., Conaghan, P. G., O'Counor, P. J., et al.: Very earl treatment with Infliximab in addition to methotrexate in early, poor-prognosis rheumatoid arthritis reduces magnetic resonance imaging evidence of synovitis and damage, with sustained benefit after inf liximab withdrawal: results from a twelve -month ran-domized, double-blind, placebo-controlled trial. Arthritis Rheum., 52: 27-35, 2005. 6) van der Heijde, D.: Plain X-rays in rheumatoid arthritis: overview of scoring methods, their reliability and Applicability. Baillieres Clin. Rheum., 10: 435-453, 1996. 2) Larsen, A., Thoen, J.: Hand radiography of 200 patients with rheumatoid arthritis repeated after an interval of one year. Scand J. Rheum., 16: 395-401, 1987. 5) Sharp, J. T., Wolfe, F., Mitchell, D. M., et al.: The progression of erosion and joint space narrowing scores in rheumatoid arthritis during the first twenty-five of disease. Arthritis Rheum., 34: 660-668, 1991. 1) Goekoop-Ruiterman, Y. P., de Vries-Bouwstra, J. K., Allaart, C. F., et al.: Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis. (the Best study) : a raundomized, controlled trial. Arthritis Rheum., 52: 3381-3390, 2005. |
| References_xml | – reference: 1) Goekoop-Ruiterman, Y. P., de Vries-Bouwstra, J. K., Allaart, C. F., et al.: Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis. (the Best study) : a raundomized, controlled trial. Arthritis Rheum., 52: 3381-3390, 2005. – reference: 3) Lipsky, P. E., van der Heijde, M. F. M., et al.: Infliximab and methotrexate in the Treatment of rheumatoid arthritis. N Engl. J. Med., 30: 1594-1602, 2000. – reference: 5) Sharp, J. T., Wolfe, F., Mitchell, D. M., et al.: The progression of erosion and joint space narrowing scores in rheumatoid arthritis during the first twenty-five of disease. Arthritis Rheum., 34: 660-668, 1991. – reference: 4) Quinn, M. A., Conaghan, P. G., O'Counor, P. J., et al.: Very earl treatment with Infliximab in addition to methotrexate in early, poor-prognosis rheumatoid arthritis reduces magnetic resonance imaging evidence of synovitis and damage, with sustained benefit after inf liximab withdrawal: results from a twelve -month ran-domized, double-blind, placebo-controlled trial. Arthritis Rheum., 52: 27-35, 2005. – reference: 2) Larsen, A., Thoen, J.: Hand radiography of 200 patients with rheumatoid arthritis repeated after an interval of one year. Scand J. Rheum., 16: 395-401, 1987. – reference: 6) van der Heijde, D.: Plain X-rays in rheumatoid arthritis: overview of scoring methods, their reliability and Applicability. Baillieres Clin. Rheum., 10: 435-453, 1996. |
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| Title | A Review of the Prevention of Joint Destruction by the Biologics |
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