A Review of the Prevention of Joint Destruction by the Biologics

• Published in: Japanese Journal of Joint Diseases Vol. 27; no. 1; pp. 25 - 30
• Main Author: SAKURAI, Takeo
• Format: Journal Article
• Language: English; Japanese
• Published: Japanese Society for Joint Diseases 30.04.2008
• Subjects: biologics; prevention of joint destruction; rheumatoid arthritis
• ISSN: 1883-2873; 1884-9067
• DOI: 10.11551/jsjd2008.27.25

Objectives: To review the prevention of joint destruction by the biologic agent, Inflixmab .To review the prevention of joint destruction at the knee joint, which is a large weiht-bearing joint, and in both hands, which represent a small affected joint. Methods: We evaluated 33 X ray images of both hands of tamed over more than 2 years according to the modified Sharps score Genant: Moreover, we evaluated A-P X ray image 31 knee joints from 19 subjects according to the Larsen grade. Results: In the evaluation by the modified Sharp score, the bone erosion scores improved from 0 to -0.21 and improvement was sustained 1 year up to 2 years later. The total score improved from 0 to -0.210.17 and improvement was sustained for 1 year up to 2 years. The joint narrowing score was aggravated from 0 to + 0.04 and improvement was sustained for 1 year up to 2 years later. In the evaluation by the Larsen grade, only 2 knees became aggravated. There were some cases in which the bone erosion improved. Conclusion: The prevention of joint destruction by the biologics (Infliximab) was evident in the knee joint, which is a large whight-bearing joint.