The Clinical Usefulness of Tramadol

Tramadol is an opioid analgesic which is prescribed worldwide. Hydrochloride oral and injectable formulations have been approved for cancer pain and postoperative pain (injection only) in Japan. In addition, tablets combining tramadol with acetaminophen have been administrated for non-cancer pain an...

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Bibliographic Details
Published inTHE JOURNAL OF JAPAN SOCIETY FOR CLINICAL ANESTHESIA Vol. 33; no. 1; pp. 041 - 050
Main Author KAWAI, Koji
Format Journal Article
LanguageJapanese
Published THE JAPAN SOCIETY FOR CLINICAL ANESTHESIA 2013
Subjects
Chronic pain
Musculoskeletal pain
Non-cancer pain
Pain management
Tramadol
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ISSN0285-4945
1349-9149
DOI10.2199/jjsca.33.041

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Summary:Tramadol is an opioid analgesic which is prescribed worldwide. Hydrochloride oral and injectable formulations have been approved for cancer pain and postoperative pain (injection only) in Japan. In addition, tablets combining tramadol with acetaminophen have been administrated for non-cancer pain and post-tooth-extraction pain. Tramadol acts as a μ-opioid receptor agonist and inhibits the reuptake of serotonin and norepinephrine. Regarding the management of cancer pain, it is placed on the second step of the World Health Organization analgesic ladder. Tramadol is gradually coming into use as a relatively safe and less addictive drug among opioid analgesics for both cancer and non-cancer pain.
ISSN:0285-4945
1349-9149
DOI:10.2199/jjsca.33.041