3D imaging of skin physiological function using optical coherence tomography-based angiography

• Published in: Transactions of Japanese Society for Medical and Biological Engineering Vol. Annual59; no. Abstract; p. 269
• Main Author: Nakamichi, Yu
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society for Medical and Biological Engineering 2021; 公益社団法人 日本生体医工学会
• ISSN: 1347-443X; 1881-4379
• DOI: 10.11239/jsmbe.Annual59.269

Skin has various physiological functions and three-dimensional detection of microcirculation within the skin is essential to evaluate and diagnose the skin physiological functions. In this study, a three-dimensional imaging technique of the skin physiological function using optical coherence tomography-based angiography (OCTA) is proposed. OCTA is a method to three-dimensionally visualize vascular networks within the tissue by detecting instantaneous variances in OCT signals that correlate with blood flow velocity. The proposed method gives a stimulus to the skin, continuously detects responses to the stimulus in vascular networks and blood flow velocities with OCTA, and evaluates the skin physiological functions. In this presentation, to test the feasibility I made a validation experiment where an alcohol stimulus was given to the skin and responses to the alcohol stimulus were detected. The utility of the method was investigated by making a comparison between the experimental results and alcohol tolerance of the subjects.