A closed-loop brain computer interface for real-time seizure detection and control

• Published in: 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Vol. 2010; pp. 4950 - 4953
• Main Authors: Liang, Sheng-Fu, Shaw, Fu-Zen, Young, Chung-Ping, Chang, Da-Wei, Liao, Yi-Cheng
• Format: Conference Proceeding Journal Article
• Language: English
• Published: United States IEEE 01.01.2010
• Subjects: Animals; Biofeedback, Psychology - instrumentation; brain computer interface; brain stimulation; Computer Systems; Deep Brain Stimulation - instrumentation; Discharges; Electroencephalography; Electroencephalography - instrumentation; Entropy; Epilepsy; Equipment Design; Equipment Failure Analysis; Rats; Real time systems; seizure detection and control; Seizures - diagnosis; Seizures - prevention & control; Signal Processing, Computer-Assisted - instrumentation; Therapy, Computer-Assisted - methods; User-Computer Interface; Wireless communication; wireless transmission
• ISBN: 1424441234; 9781424441235
• ISSN: 1094-687X; 1557-170X
• DOI: 10.1109/IEMBS.2010.5627243

The worldwide prevalence of epilepsy is approximately 1%, and 25% of epilepsy patients cannot be treated sufficiently by available therapies. Brain stimulation with closed-loop seizure control has recently been proposed as an innovative and effective alternative. In this paper, a portable closed-loop brain computer interface for seizure control was developed and shown with several aspects of advantages, including high seizure detection rate (92-99% during wake-sleep states), low false detection rate (1.2-2.5%), and small size. The seizure detection and electrical stimulation latency was not greater than 0.6 s after seizure onset. A wireless communication feature also provided flexibility for subjects freeing from the hassle of wires. Experimental data from freely moving rats supported the functional possibility of a real-time closed-loop seizure controller.