Differences in gastric cancer survival between the U.S. and China

• Published in: Journal of surgical oncology Vol. 112; no. 1; pp. 31 - 37
• Main Authors: Strong, Vivian E., Wu, Ai-wen, Selby, Luke V., Gonen, Mithat, Hsu, Meier, Song, Kyo Young, Park, Cho Hyun, Coit, Daniel G., Ji, Jia-fu, Brennan, Murray F.
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.07.2015; Wiley Subscription Services, Inc
• Subjects: Adenocarcinoma - epidemiology; Adenocarcinoma - mortality; Adenocarcinoma - pathology; Adenocarcinoma - surgery; Adult; Aged; Aged, 80 and over; China - epidemiology; Female; Follow-Up Studies; gastrectomy; Gastrectomy - mortality; gastric cancer; Humans; Male; Middle Aged; Neoplasm Staging; Prognosis; Stomach Neoplasms - epidemiology; Stomach Neoplasms - mortality; Stomach Neoplasms - pathology; Stomach Neoplasms - surgery; Survival Rate; United States - epidemiology; Young Adult; United States; China; gastric cancer; gastrectomy
• ISSN: 0022-4790; 1096-9098; 1096-9098
• DOI: 10.1002/jso.23940

Background Previous comparisons of gastric cancer between the West and the East have focused predominantly on Japan and Korea, where early gastric cancer is prevalent, and have not included the Chinese experience, which accounts for approximately half the world's gastric cancer. Methods Patient characteristics, surgical procedures, pathologic information, and survival were compared among gastric cancer patients who underwent curative intent gastrectomy at two large volume cancer centers in China and the US between 1995 and 2005. Results Median age and body mass index were significantly higher in US patients. The proportion of proximal gastric cancer was comparable. Gastric cancer patients in China had larger tumors and a later stage at presentation. The median number of positive lymph nodes was higher (5 vs 4, P < 0.02) despite a lower lymph node retrieval (16 vs 22, P < 0.001) in Chinese patients. The probability of death due to gastric cancer in Chinese patients was 1.7 fold of that in the US (P < 0.0001) after adjusting for important prognostic factors. Conclusions Even after adjusting for important prognostic factors Chinese gastric cancer patients have a worse outcome than US gastric cancer patients. The differences between Chinese and US gastric cancer are a potential resource for understanding the disease. J. Surg. Oncol. 2015 111:31–37. © 2015 Wiley Periodicals, Inc.