Fluid management in pediatric patients with DKA and rates of suspected clinical cerebral edema

• Published in: Pediatric diabetes Vol. 16; no. 5; pp. 338 - 344
• Main Authors: Hsia, Daniel S, Tarai, Sarah G, Alimi, Amir, Coss-Bu, Jorge A, Haymond, Morey W
• Format: Journal Article
• Language: English
• Published: Former Munksgaard John Wiley & Sons A/S 01.08.2015
• Subjects: Adolescent; Brain Edema - epidemiology; Brain Edema - etiology; cerebral edema; Child; diabetic ketoacidosis; Diabetic Ketoacidosis - complications; Diabetic Ketoacidosis - epidemiology; Diabetic Ketoacidosis - therapy; Female; Fluid Therapy - methods; Fluid Therapy - statistics & numerical data; Humans; Incidence; Isotonic Solutions - therapeutic use; Male; practice guidelines; Retrospective Studies; Sodium Chloride - therapeutic use; Treatment Outcome; diabetic ketoacidosis; cerebral edema; practice guidelines
• ISSN: 1399-543X; 1399-5448; 1399-5448
• DOI: 10.1111/pedi.12268

Objective To compare outcomes of diabetic ketoacidosis (DKA) 6 yrs before and 6 yrs after changing rehydration fluids from ½ normal saline to Lactated Ringer's and decreasing the total intended fluid volume administered in the first 24 hrs from 3500 mL/m2/d to ≤ 2500 mL/m2/d at Texas Children's Hospital (TCH) in response to recommendations by the ESPE, LWPES, and ISPAD in 2004. Subjects/Methods A retrospective cohort study was conducted in which 1868 admissions for DKA were identified and reviewed. The cohort was divided into two groups: Group A, 1998–2004, and Group B, 2004–2010. Subjects with suspected clinical cerebral edema and adverse outcomes were identified. Results Although not statistically significant, there was an equal number (n = 3) of adverse outcomes (death or neurological damage) in each group despite more than double the admissions in Group B (1264) compared with those in Group A (604). Overall, the incidence of suspected clinical cerebral edema was more than double for those admissions in which fluid resuscitation was initiated at an outside hospital (OSH) vs. at TCH (13.6 vs. 5.3%, p < 0.001). Conclusions Decreasing the intended fluid rate during the initial 24 hrs to 2500 mL/m2/d and increasing the IV fluid sodium content did not significantly decrease the incidence of adverse outcomes in children with DKA. However, children transferred from an OSH had a higher incidence of suspected clinical cerebral edema. Thus, we need to more readily share our management protocols with the emergency rooms of local referring hospitals to potentially decrease the incidence of suspected clinical cerebral edema and adverse outcomes in children transferred with DKA.