Balloon type elasticity sensing for left ventricle of small laboratory animal

• Published in: 2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society Vol. 2011; pp. 904 - 907
• Main Authors: Ishii, Ryohei, Higashimori, Mitsuru, Tadakuma, Kenjiro, Kaneko, Makoto, Tamaki, Shunsuke, Sakata, Yasushi, Yamamoto, Kazuhiro
• Format: Conference Proceeding Journal Article
• Language: English
• Published: United States IEEE 01.01.2011
• Subjects: Animals; Cardiac Catheterization - instrumentation; Catheterization - instrumentation; Computer Simulation; Elastic Modulus; Elasticity; Equipment Design; Equipment Failure Analysis; Hardness Tests - instrumentation; Heart; Heart Failure - complications; Heart Failure - diagnosis; Heart Failure - physiopathology; Heart Ventricles - physiopathology; Mice; Models, Cardiovascular; Rats; Reproducibility of Results; Sensitivity and Specificity; Sensors; Strain; Ventricular Dysfunction, Left - diagnosis; Ventricular Dysfunction, Left - etiology; Ventricular Dysfunction, Left - physiopathology; Young's modulus
• ISBN: 9781424441211; 1424441218
• ISSN: 1094-687X; 1557-170X
• DOI: 10.1109/IEMBS.2011.6090202

This paper describes an elasticity sensing system for left ventricle of small laboratory animal. We first show the basic concept of the proposed method, where a ring shaped specimen is dilated by a balloon type probe using a pressure based control, and the elasticity of the specimen is estimated by using the stress and strain information. We introduce a dual cylinder model for approximating the strengths of the specimen's material and the balloon. Based on this model, we can derive Young's modulus of the specimen. After explaining the developed experimental system, we show a couple of experimental results using rats and mice, where HFPEF (Heart Failure Preserved Ejection Fraction) group can be distinguished from a normal group.