Prognostic value of pretreatment 18F-fluorodeoxyglucose positron emission tomography/CT volume-based parameters in patients with oropharyngeal squamous cell carcinoma with known p16 and p53 status

• Published in: Head & neck Vol. 37; no. 10; pp. 1524 - 1531
• Main Authors: Kikuchi, Masahiro, Koyasu, Sho, Shinohara, Shogo, Usami, Yu, Imai, Yukihiro, Hino, Megumu, Itoh, Kyo, Tona, Risa, Kanazawa, Yuji, Kishimoto, Ippei, Harada, Hiroyuki, Naito, Yasushi
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.10.2015; Wiley Subscription Services, Inc
• Subjects: 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT; Adult; Aged; Carcinoma, Squamous Cell - diagnostic imaging; Carcinoma, Squamous Cell - metabolism; Carcinoma, Squamous Cell - pathology; Cone-Beam Computed Tomography; Cyclin-Dependent Kinase Inhibitor p16; Female; Fluorodeoxyglucose F18 - administration & dosage; Head and Neck Neoplasms - diagnostic imaging; Head and Neck Neoplasms - metabolism; Head and Neck Neoplasms - pathology; human papillomavirus (HPV); Humans; Male; Middle Aged; Neoplasm Proteins - metabolism; Neoplasm Staging; Oropharyngeal Neoplasms - diagnostic imaging; Oropharyngeal Neoplasms - metabolism; Oropharyngeal Neoplasms - pathology; oropharyngeal squamous cell carcinoma; p16; p53; Positron-Emission Tomography - methods; Prognosis; Proportional Hazards Models; Radiopharmaceuticals - administration & dosage; Retrospective Studies; Squamous Cell Carcinoma of Head and Neck; Survival Rate; Tomography, X-Ray Computed - methods; Tumor Suppressor Protein p53 - metabolism; 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT; human papillomavirus (HPV); p16; oropharyngeal squamous cell carcinoma; p53
• ISSN: 1043-3074; 1097-0347; 1097-0347
• DOI: 10.1002/hed.23784

Background The purpose of this study was to determine whether pretreatment 18F‐fluorodeoxyglucose‐positron emission tomography (18F‐FDG PET/CT) volume‐based parameters, such as metabolic tumor volume and total lesion glycolysis, add more prognostic information in patients with oropharyngeal squamous cell carcinoma (SCC). Methods The subjects were 47 patients with oropharyngeal SCC who underwent 18F‐FDG PET/CT before any treatment and followed by definitive therapy. PET parameters (metabolic tumor volume and total lesion glycolysis) and tumor p16/p53 status were evaluated retrospectively. Univariate and multivariate analyses were performed for disease‐free survival (DFS), disease‐specific survival (DSS), and overall survival (OS). Results All volume‐based PET parameters were found to be significant prognostic factors for DFS, DSS, and OS in univariate analysis. In multivariate analysis, only metabolic tumor volume for total tumor lesions (cutoff 65) retained an independent association with DFS, DSS, and OS. Conclusion Metabolic tumor volume for total tumor lesions may be a predictive marker for survival outcomes in patients with oropharyngeal SCC with known p16/p53 status. © 2014 Wiley Periodicals, Inc. Head Neck 37: 1524–1531, 2015