A method for normalizing histology slides for quantitative analysis

Inconsistencies in the preparation of histology slides make it difficult to perform quantitative analysis on their results. In this paper we provide two mechanisms for overcoming many of the known inconsistencies in the staining process, thereby bringing slides that were processed or stored under ve...

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Bibliographic Details
Published in2009 IEEE International Symposium on Biomedical Imaging: From Nano to Macro pp. 1107 - 1110
Main Authors Macenko, M., Niethammer, M., Marron, J.S., Borland, D., Woosley, J.T., Xiaojun Guan, Schmitt, C., Thomas, N.E.
Format Conference Proceeding
LanguageEnglish
Published IEEE 01.06.2009
Subjects
Biological cells
Biomedical image processing
Biomedical microscopy
Biomedical signal detection
Deconvolution
Detectors
Diffraction
Fluorescence
Image retrieval
Information retrieval
Maximum likelihood estimation
Melanoma
Microscopy
Pathology
Testing
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ISBN1424439310
9781424439317
ISSN1945-7928
DOI10.1109/ISBI.2009.5193250

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Summary:Inconsistencies in the preparation of histology slides make it difficult to perform quantitative analysis on their results. In this paper we provide two mechanisms for overcoming many of the known inconsistencies in the staining process, thereby bringing slides that were processed or stored under very different conditions into a common, normalized space to enable improved quantitative analysis.
ISBN:1424439310
9781424439317
ISSN:1945-7928
DOI:10.1109/ISBI.2009.5193250