Global motor unit number index sum score for assessing the loss of lower motor neurons in amyotrophic lateral sclerosis

ABSTRACT Introduction We propose a motor unit number index (MUNIX) global sum score in amyotrophic lateral sclerosis (ALS) to estimate the loss of functional motor units. Methods MUNIX was assessed for 18 ALS patients and 17 healthy controls in 7 muscles: the abductor pollicis brevis (APB), abductor...

Full description

Saved in:
Bibliographic Details
Published inMuscle & nerve Vol. 56; no. 2; pp. 202 - 206
Main Authors Grimaldi, Stephan, Duprat, Lauréline, Grapperon, Aude‐Marie, Verschueren, Annie, Delmont, Emilien, Attarian, Shahram
Format Journal Article
LanguageEnglish
Published United States Wiley Subscription Services, Inc 01.08.2017
Wiley
Subjects
Aged
ALS
Amyotrophic lateral sclerosis
Amyotrophic Lateral Sclerosis - pathology
biomarker
clinical correlation
Correlation analysis
Electromyography
Evoked Potentials, Motor - physiology
Female
Genetics
global MUNIX sum score
Human genetics
Humans
Life Sciences
Linear Models
Male
Middle Aged
Motor neurons
Motor Neurons - physiology
Motor task performance
motor unit
Motor units
MUNIX
Muscle, Skeletal - pathology
Muscle, Skeletal - physiopathology
Muscles
Neurons
Patients
Severity of Illness Index
Shoulder
Skeletal muscle
motor unit
ALS
MUNIX
global MUNIX sum score
biomarker
clinical correlation
Online AccessGet full text
ISSN0148-639X
1097-4598
DOI10.1002/mus.25595

Cover

More Information
Summary:ABSTRACT Introduction We propose a motor unit number index (MUNIX) global sum score in amyotrophic lateral sclerosis (ALS) to estimate the loss of functional motor units. Methods MUNIX was assessed for 18 ALS patients and 17 healthy controls in 7 muscles: the abductor pollicis brevis (APB), abductor digiti minimi (ADM), tibialis anterior (TA), deltoid, trapezius, submental complex, and orbicularis oris. Results MUNIX was significantly lower in ALS patients than in healthy controls for the APB, ADM, TA, and trapezius muscles. The MUNIX sum score of 4 muscles (ADM + APB + trapezius + TA) was lower in ALS patients (P = 0.01) and was correlated with clinical scores. Discussion The global MUNIX sum score proposed in this study estimates the loss of lower motor neurons in several body regions, including the trapezius, and is correlated with clinical impairment in ALS patients. Muscle Nerve 56: 202–206, 2017
Bibliography:None of the authors have any conflicts of interest to disclose.
Conflicts of Interest
Stephan Grimaldi and Lauréline Duprat contributed equally to this work.
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ISSN:0148-639X
1097-4598
DOI:10.1002/mus.25595