Disease-associated expression profiles in peripheral blood mononuclear cells from patients with advanced renal cell carcinoma

Expression profiling has demonstrated that transcriptomes of primary malignancies differ from those in normal tissue. It is unknown, however, whether there exist "surrogate" transcriptional markers in peripheral blood mononuclear cells (PBMCs) of patients with solid tumors. We identified t...

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Published inCancer research (Chicago, Ill.) Vol. 63; no. 18; pp. 6069 - 6075
Main Authors TWINE, Natalie C, STOVER, Jennifer A, SLONIM, Donna K, TREPICCHIO, William L, BURCZYNSKI, Michael E, MARSHALL, Bonnie, DUKART, Gary, HIDALGO, Manuel, STADLER, Walter, LOGAN, Theodore, DUTCHER, Janice, HUDES, Gary, DORNER, Andrew J
Format Journal Article
LanguageEnglish
Published Philadelphia, PA American Association for Cancer Research 15.09.2003
Subjects
Adult
Aged
Biological and medical sciences
Carcinoma, Renal Cell - blood
Carcinoma, Renal Cell - classification
Carcinoma, Renal Cell - genetics
Female
Gene Expression Profiling
Humans
Kidney Failure, Chronic - blood
Kidney Failure, Chronic - genetics
Kidney Neoplasms - blood
Kidney Neoplasms - classification
Kidney Neoplasms - genetics
Kidneys
Leukocytes, Mononuclear - metabolism
Leukocytes, Mononuclear - physiology
Male
Medical sciences
Middle Aged
Nephrology. Urinary tract diseases
Oligonucleotide Array Sequence Analysis
RNA, Messenger - biosynthesis
RNA, Messenger - blood
RNA, Messenger - genetics
Transcription, Genetic
Tumors of the urinary system
Kidney disease
Human
Blood cell
Urinary system disease
Carcinoma
Mononuclear cell
Gene
Grawitz tumor
Advanced stage
Malignant tumor
Diagnosis
Gene expression
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ISSN0008-5472

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Summary:Expression profiling has demonstrated that transcriptomes of primary malignancies differ from those in normal tissue. It is unknown, however, whether there exist "surrogate" transcriptional markers in peripheral blood mononuclear cells (PBMCs) of patients with solid tumors. We identified transcripts expressed differentially between PBMCs from renal cell carcinoma patients and normal subjects, some of which appear to reflect specific immune responses of circulating cells. We also identified small sets of predictor genes distinguishing PBMCs from renal cell carcinoma patients and normal volunteers with high accuracy. The present findings have important implications for diagnosis and future clinical pharmacogenomic studies of antitumor therapies.
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ISSN:0008-5472