Neutrophil polycythemia rubra vera-1 expression in classic and atypical myeloproliferative disorders and laboratory correlates

The current study of 153 subjects with both classic and atypical myeloproliferative disorders suggests that neutrophil polycythemia rubra vera-1 (PRV-1) over-expression is a non-specific feature of clonal myeloproliferation that displays significant correlation with leukocyte alkaline phosphatase sc...

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Bibliographic Details
Published inHaematologica (Roma) Vol. 90; no. 3; p. 406
Main Authors Sirhan, S, Lasho, TL, Elliott, MA, Tefferi, A
Format Journal Article
LanguageEnglish
Published Italy 01.03.2005
Subjects
Adult
Aged
Alkaline Phosphatase - analysis
Clinical Enzyme Tests
Female
GPI-Linked Proteins
Humans
Isoantigens - analysis
Isoantigens - genetics
Male
Membrane Glycoproteins - analysis
Membrane Glycoproteins - genetics
Middle Aged
Myeloproliferative Disorders - diagnosis
Neutrophils - chemistry
Receptors, Cell Surface - analysis
Receptors, Cell Surface - genetics
RNA, Messenger - analysis
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ISSN0390-6078
1592-8721
1592-8721

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Summary:The current study of 153 subjects with both classic and atypical myeloproliferative disorders suggests that neutrophil polycythemia rubra vera-1 (PRV-1) over-expression is a non-specific feature of clonal myeloproliferation that displays significant correlation with leukocyte alkaline phosphatase score. These observations undermine the utility of the PRV-1 assay as a diagnostic test of additional value.
Bibliography:content type line 23
SourceType-Scholarly Journals-1
ObjectType-Correspondence-1
ISSN:0390-6078
1592-8721
1592-8721