Initial Experience with Technetium-99m HM-PAO Brain SPECT

Technetium-99m hexamethylpropyleneamineoxime ([99mTc]HM-PAO) brain single photon emission computed tomography (SPECT) was performed with a dual head rotating scintillation camera. Normal tracer distribution and side/side differences of counting rates were obtained in 11 healthy volunteers. Almost st...

Full description

Saved in:
Bibliographic Details
Published inThe Journal of nuclear medicine (1978) Vol. 28; no. 11; p. 1657
Main Authors Podreka, I, Suess, E, Goldenberg, G, Steiner, M, Brucke, T, Muller, Ch, Lang, W, Neirinckx, R.D, Deecke, L
Format Journal Article
LanguageEnglish
Published United States Soc Nuclear Med 01.11.1987
Subjects
Online AccessGet full text
ISSN0161-5505
1535-5667

Cover

Abstract Technetium-99m hexamethylpropyleneamineoxime ([99mTc]HM-PAO) brain single photon emission computed tomography (SPECT) was performed with a dual head rotating scintillation camera. Normal tracer distribution and side/side differences of counting rates were obtained in 11 healthy volunteers. Almost stable gray/white matter ratios were found (1.97-2.1) in one normal subject during 2 hr after tracer administration. Eighty-three investigated patients had the following diagnoses (in parentheses is percent of positive findings in each group): cerebral vascular disease 18 (94.4%), epilepsy 23 (82.6%), extrapyramidal disorders 8 (100%), dementia 12 (100%), headache 11 (63.6%), psychiatric disorders 11 (27.3%). In addition, SPECT was performed in 28 male volunteers during motor or visual imagery tasks and a significant increase (p = 0.035) of relative tracer deposition was observed in the left inferior occipital region during visual imagery when compared with motor imagery. The results indicate that [99mTc]HM-PAO SPECT is valuable for demonstrating pathologic and physiologic changes of the brain.
AbstractList Technetium-99m hexamethylpropyleneamineoxime ([99mTc]HM-PAO) brain single photon emission computed tomography (SPECT) was performed with a dual head rotating scintillation camera. Normal tracer distribution and side/side differences of counting rates were obtained in 11 healthy volunteers. Almost stable gray/white matter ratios were found (1.97-2.1) in one normal subject during 2 hr after tracer administration. Eighty-three investigated patients had the following diagnoses (in parentheses is percent of positive findings in each group): cerebral vascular disease 18 (94.4%), epilepsy 23 (82.6%), extrapyramidal disorders 8 (100%), dementia 12 (100%), headache 11 (63.6%), psychiatric disorders 11 (27.3%). In addition, SPECT was performed in 28 male volunteers during motor or visual imagery tasks and a significant increase (p = 0.035) of relative tracer deposition was observed in the left inferior occipital region during visual imagery when compared with motor imagery. The results indicate that [99mTc]HM-PAO SPECT is valuable for demonstrating pathologic and physiologic changes of the brain.
Technetium-99m hexamethylpropyleneamineoxime ([99mTc]HM-PAO) brain single photon emission computed tomography (SPECT) was performed with a dual head rotating scintillation camera. Normal tracer distribution and side/side differences of counting rates were obtained in 11 healthy volunteers. Almost stable gray/white matter ratios were found (1.97-2.1) in one normal subject during 2 hr after tracer administration. Eighty-three investigated patients had the following diagnoses (in parentheses is percent of positive findings in each group): cerebral vascular disease 18 (94.4%), epilepsy 23 (82.6%), extrapyramidal disorders 8 (100%), dementia 12 (100%), headache 11 (63.6%), psychiatric disorders 11 (27.3%). In addition, SPECT was performed in 28 male volunteers during motor or visual imagery tasks and a significant increase (p = 0.035) of relative tracer deposition was observed in the left inferior occipital region during visual imagery when compared with motor imagery. The results indicate that [99mTc]HM-PAO SPECT is valuable for demonstrating pathologic and physiologic changes of the brain.Technetium-99m hexamethylpropyleneamineoxime ([99mTc]HM-PAO) brain single photon emission computed tomography (SPECT) was performed with a dual head rotating scintillation camera. Normal tracer distribution and side/side differences of counting rates were obtained in 11 healthy volunteers. Almost stable gray/white matter ratios were found (1.97-2.1) in one normal subject during 2 hr after tracer administration. Eighty-three investigated patients had the following diagnoses (in parentheses is percent of positive findings in each group): cerebral vascular disease 18 (94.4%), epilepsy 23 (82.6%), extrapyramidal disorders 8 (100%), dementia 12 (100%), headache 11 (63.6%), psychiatric disorders 11 (27.3%). In addition, SPECT was performed in 28 male volunteers during motor or visual imagery tasks and a significant increase (p = 0.035) of relative tracer deposition was observed in the left inferior occipital region during visual imagery when compared with motor imagery. The results indicate that [99mTc]HM-PAO SPECT is valuable for demonstrating pathologic and physiologic changes of the brain.
Author Podreka, I
Suess, E
Deecke, L
Lang, W
Neirinckx, R.D
Steiner, M
Muller, Ch
Brucke, T
Goldenberg, G
Author_xml – sequence: 1
  fullname: Podreka, I
– sequence: 2
  fullname: Suess, E
– sequence: 3
  fullname: Goldenberg, G
– sequence: 4
  fullname: Steiner, M
– sequence: 5
  fullname: Brucke, T
– sequence: 6
  fullname: Muller, Ch
– sequence: 7
  fullname: Lang, W
– sequence: 8
  fullname: Neirinckx, R.D
– sequence: 9
  fullname: Deecke, L
BackLink https://www.ncbi.nlm.nih.gov/pubmed/3499489$$D View this record in MEDLINE/PubMed
BookMark eNotj11rwjAYhcNwOHX7CYNejd0E8tGkyaUTNwWHwtx1SNO3a6RNXdri9u_n0Ktz8TznwJmiUWgD3KAJFVxgIWU2QhNCJcVCEHGHpl13IIRIpdQYjXmqdar0BOl18L23dbL8OUL0EBwkJ99XyR5cFaD3Q4O1bpLVO97Nt8lLtD4kH7vlYn-Pbktbd_BwzRn6fF3uFyu82b6tF_MNrqhIe8xkUVhV5lKUMqO5lWUKhZSyoERqICp1kDNOuONa5bYkGbMsL11GgTLiWMZn6Omye4zt9wBdbxrfOahrG6AdOqMoyc5ddRYfr-KQN1CYY_SNjb_m-vXMny-88l_VyUcwYXA12PgvH0LDlKHUUCky_gfkfF5u
ContentType Journal Article
DBID CGR
CUY
CVF
ECM
EIF
NPM
7X8
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
MEDLINE - Academic
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
DatabaseTitleList MEDLINE
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1535-5667
ExternalDocumentID 3499489
jnm28_11_1657
Genre Journal Article
GroupedDBID -
08R
2WC
3O-
53G
55
5RE
8WZ
A6W
ABEFU
ABFLS
ABSGY
ACGOD
ACIWK
ACPRK
ADACO
ADBIT
ADDZX
AENEX
AFFNX
AFRAH
AHMBA
ALMA_UNASSIGNED_HOLDINGS
CS3
DIK
DU5
E3Z
EBS
EJD
F5P
FH7
GJ
H13
I-F
IL9
INIJC
J5H
KQ8
L7B
OK1
P2P
R0Z
RHF
RHI
RNS
SJN
SV3
TSM
VH1
WH7
WOQ
X
X7M
YQJ
ZA5
ZGI
ZXP
---
-~X
.55
.GJ
29L
41~
7RV
7X7
88E
88I
8AF
8AO
8FE
8FG
8FH
8FI
8FJ
8R4
8R5
ABSQV
ABUWG
ADMOG
AFKRA
AFOSN
AI.
ALIPV
ARAPS
AZQEC
BBNVY
BENPR
BGLVJ
BHPHI
BKEYQ
BPHCQ
BVXVI
CCPQU
CGR
CUY
CVF
DWQXO
EBD
ECM
EIF
EMOBN
EX3
F9R
FYUFA
GNUQQ
HCIFZ
HMCUK
LK8
M1P
M2P
M2Q
M7P
N4W
NAPCQ
NPM
P62
PHGZM
PHGZT
PJZUB
PPXIY
PQGLB
PQQKQ
PROAC
PSQYO
Q2X
RWL
S0X
TAE
TR2
TUS
UKHRP
W8F
WOW
YHG
7X8
ID FETCH-LOGICAL-h154t-26dda8fb65f671ba6f4ed666d1069e084ceb2303c398baf072a2bfc71e120c273
ISSN 0161-5505
IngestDate Sun Aug 24 04:02:55 EDT 2025
Tue Aug 05 11:36:36 EDT 2025
Mon Jan 18 12:02:59 EST 2021
IsPeerReviewed true
IsScholarly true
Issue 11
Language English
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-h154t-26dda8fb65f671ba6f4ed666d1069e084ceb2303c398baf072a2bfc71e120c273
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
PMID 3499489
PQID 81073988
PQPubID 23479
ParticipantIDs proquest_miscellaneous_81073988
pubmed_primary_3499489
highwire_nuclearmed_jnm28_11_1657
ProviderPackageCode RHF
RHI
PublicationCentury 1900
PublicationDate 1987-Nov
PublicationDateYYYYMMDD 1987-11-01
PublicationDate_xml – month: 11
  year: 1987
  text: 1987-Nov
PublicationDecade 1980
PublicationPlace United States
PublicationPlace_xml – name: United States
PublicationTitle The Journal of nuclear medicine (1978)
PublicationTitleAlternate J Nucl Med
PublicationYear 1987
Publisher Soc Nuclear Med
Publisher_xml – name: Soc Nuclear Med
SSID ssj0006888
Score 1.6566211
Snippet Technetium-99m hexamethylpropyleneamineoxime ([99mTc]HM-PAO) brain single photon emission computed tomography (SPECT) was performed with a dual head rotating...
SourceID proquest
pubmed
highwire
SourceType Aggregation Database
Index Database
Publisher
StartPage 1657
SubjectTerms Adult
Aged
Basal Ganglia Diseases - diagnostic imaging
Brain - diagnostic imaging
Cerebrovascular Circulation
Cerebrovascular Disorders - diagnostic imaging
Dementia - physiopathology
Epilepsy - diagnostic imaging
Female
Headache - diagnostic imaging
Humans
Imagination - physiology
Male
Mental Disorders - physiopathology
Middle Aged
Organometallic Compounds
Oximes
Technetium
Technetium Tc 99m Exametazime
Tomography, Emission-Computed
Title Initial Experience with Technetium-99m HM-PAO Brain SPECT
URI http://jnm.snmjournals.org/cgi/content/abstract/28/11/1657
https://www.ncbi.nlm.nih.gov/pubmed/3499489
https://www.proquest.com/docview/81073988
Volume 28
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVAFT
  databaseName: Open Access Digital Library
  customDbUrl:
  eissn: 1535-5667
  dateEnd: 20250330
  omitProxy: true
  ssIdentifier: ssj0006888
  issn: 0161-5505
  databaseCode: KQ8
  dateStart: 19640101
  isFulltext: true
  titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html
  providerName: Colorado Alliance of Research Libraries
– providerCode: PRVBFR
  databaseName: Free Medical Journals
  customDbUrl:
  eissn: 1535-5667
  dateEnd: 20240930
  omitProxy: true
  ssIdentifier: ssj0006888
  issn: 0161-5505
  databaseCode: DIK
  dateStart: 19640101
  isFulltext: true
  titleUrlDefault: http://www.freemedicaljournals.com
  providerName: Flying Publisher
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnZ1LS8NAEIAXW1B6EZ9YnxG8lUh3k2w2R5FqFaqVVvAWso_go01LTS_-emeTbZKKgnoJIQkhzLdM5rEzg9AZlz5ofcLBcvOI7boe6EEFhpykQgXKJ2Ck6Ixu7452H93bJ--pnPaWVZek_Fx8fFtX8h-qcA246irZP5AtXgoX4Bz4whEIw_FXjG_0zh-QsSr6FZu4qo6Xq_RlPraDYNzq9uz-xX2L62kQrUG_czmsmqRlcdgo39Uh9CSJIumedXICJ7ASMuhP5Ey9RUsx1wH8XpYrG64nI1luHytGeA30eM18nfTKkIMOSpjau0oUkmJbuzZVNUpYdbngilLENO9BXSEyHWdIHPC33HyE0Jeu1-ZODdVAIelc-0PZBJ6ybJxo8RUNtGoer3R5_tljyCyH4QZaN7K1LnJ-m2hFJVtorWfku40Cg9EqMVoao7WM0coxWhlGK8O4gx6vOsPLrm0mWtjPYKqmNqFSRizm1Iupj3lEY1dJcCAlOOaBajNXKA4-oSOcgPEobvskIjwWPlaYtAVYmruonkwStYcsLrDEThwLULpuHCkuuIMd8HcjwV3JvSY6XYgiNCsHJBC-JmPCwO0LNZQmOlnIKAStolNFUaIm8_eQYZ3BZayJdnPRhdO8-UloJL3_040D1CiXzCGqp7O5OgK7LeXHGcVPqWxBIA
linkProvider Colorado Alliance of Research Libraries
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Initial+experience+with+technetium-99m+HM-PAO+brain+SPECT&rft.jtitle=The+Journal+of+nuclear+medicine+%281978%29&rft.au=Podreka%2C+I&rft.au=Suess%2C+E&rft.au=Goldenberg%2C+G&rft.au=Steiner%2C+M&rft.date=1987-11-01&rft.issn=0161-5505&rft.volume=28&rft.issue=11&rft.spage=1657&rft_id=info%3Apmid%2F3499489&rft.externalDocID=3499489
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0161-5505&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0161-5505&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0161-5505&client=summon