Initial Experience with Technetium-99m HM-PAO Brain SPECT

• Published in: The Journal of nuclear medicine (1978) Vol. 28; no. 11; p. 1657
• Main Authors: Podreka, I, Suess, E, Goldenberg, G, Steiner, M, Brucke, T, Muller, Ch, Lang, W, Neirinckx, R.D, Deecke, L
• Format: Journal Article
• Language: English
• Published: United States Soc Nuclear Med 01.11.1987
• Subjects: Adult; Aged; Basal Ganglia Diseases - diagnostic imaging; Brain - diagnostic imaging; Cerebrovascular Circulation; Cerebrovascular Disorders - diagnostic imaging; Dementia - physiopathology; Epilepsy - diagnostic imaging; Female; Headache - diagnostic imaging; Humans; Imagination - physiology; Male; Mental Disorders - physiopathology; Middle Aged; Organometallic Compounds; Oximes; Technetium; Technetium Tc 99m Exametazime; Tomography, Emission-Computed
• ISSN: 0161-5505; 1535-5667

Technetium-99m hexamethylpropyleneamineoxime ([99mTc]HM-PAO) brain single photon emission computed tomography (SPECT) was performed with a dual head rotating scintillation camera. Normal tracer distribution and side/side differences of counting rates were obtained in 11 healthy volunteers. Almost stable gray/white matter ratios were found (1.97-2.1) in one normal subject during 2 hr after tracer administration. Eighty-three investigated patients had the following diagnoses (in parentheses is percent of positive findings in each group): cerebral vascular disease 18 (94.4%), epilepsy 23 (82.6%), extrapyramidal disorders 8 (100%), dementia 12 (100%), headache 11 (63.6%), psychiatric disorders 11 (27.3%). In addition, SPECT was performed in 28 male volunteers during motor or visual imagery tasks and a significant increase (p = 0.035) of relative tracer deposition was observed in the left inferior occipital region during visual imagery when compared with motor imagery. The results indicate that [99mTc]HM-PAO SPECT is valuable for demonstrating pathologic and physiologic changes of the brain.