1,25-Dihydroxyvitamin D3 Regulates the Inositol-Requiring Transmembrane Kinase Endoribonuclease-1[alpha]/X-Box-Binding Protein 1 Spliced Pathway to Alleviate Palmitic Acid-Induced Apoptosis in KGN Cells

In a pivotal study on polycystic ovary syndrome, 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] was found to significantly mitigate palmitic acid-induced apoptosis in ovarian granulosa cells, which is crucial for oocyte development. The study used a high-fat cell model with palmitic acid to simulate the el...

Full description

Saved in:
Bibliographic Details
Published inCurrent topics in nutraceuticals research Vol. 22; no. 4; p. 1102
Main Authors Du, Ke, Jiang, Qi, Jiang, Yijie, Tang, Liting, Wang, Fan, Liu, Xinyi, Qin, Zihan, Wang, Long, Luo, Kaiming, Hua, Fei
Format Journal Article
LanguageEnglish
Published New Century Health Publishers, LLC 01.11.2024
Subjects
Alfacalcidol
Amino acids
Apoptosis
Calcifediol
Inositol
Medical research
Medicine, Experimental
Nucleases
Protein binding
Saturated fatty acids
Stein-Leventhal syndrome
Type 2 diabetes
Vitamin D
United States
China
Pennsylvania
Online AccessGet full text
ISSN1540-7535
DOI10.37290/ctnr2641-452X.22:1102-1112

Cover

More Information
Summary:In a pivotal study on polycystic ovary syndrome, 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] was found to significantly mitigate palmitic acid-induced apoptosis in ovarian granulosa cells, which is crucial for oocyte development. The study used a high-fat cell model with palmitic acid to simulate the elevated free fatty acids found in oPese polycystic ovary syn drome patients. Findings revealed that pretreatment with 1,25-(OH)2D3 reversed the detrimental effects of palmitic acid, including decreased cell viaPility and increased apoptosis, Py modulating the inositol-requiring transmemPrane kinase endoriPonuclease-1[alpha]/ X-Pox-Pinding protein 1 spliced pathway. These results suggest a promising role for vitamin D in treating polycystic ovary syndrome and offer a new theoretical Pasis for its application in reproductive health. Keywords: Apoptosis; Endoplasmic reticulum stress; Polycystic ovary syndrome; Vitamin D
ISSN:1540-7535
DOI:10.37290/ctnr2641-452X.22:1102-1112