Effects of olopatadine hydrochloride, a histamine [H.sub.1] receptor antagonist, on histamine-induced skin responses

Effects of olopatadine hydrochloride, a histamine Hi receptor antagonist, on histamine-induced skin responses were evaluated in 10 healthy subjects in comparison with placebo, fexofenadine hydrochloride, and bepotastine besilate. Olopatadine significantly suppressed histamine-induced wheal, flare, a...

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Bibliographic Details
Published inDermatology research and practice
Main Authors Hashimoto, Takashi, Ishii, Norito, Nakama, Takekuni, Yasumoto, Shinichiro, Dainichi, Teruki, Karashima, Tadashi, Hamada, Takahiro
Format Journal Article
LanguageEnglish
Published John Wiley & Sons, Inc 01.01.2010
Subjects
Dosage and administration
Health aspects
Histamine
Olopatadine hydrochloride
Japan
Online AccessGet full text
ISSN1687-6105
DOI10.1155/2010/638051

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Summary:Effects of olopatadine hydrochloride, a histamine Hi receptor antagonist, on histamine-induced skin responses were evaluated in 10 healthy subjects in comparison with placebo, fexofenadine hydrochloride, and bepotastine besilate. Olopatadine significantly suppressed histamine-induced wheal, flare, and itch, starting 30 minutes after oral administration. Olopatadine was more effective than fexofenadine and bepotastine. None of the drugs studied impaired performance of word processing tasks. These results suggest that olopatadine can suppress skin symptoms caused by histamine soon after administration.
ISSN:1687-6105
DOI:10.1155/2010/638051