Novel Soy Germ Pasta Enriched in Isoflavones Ameliorates Gastroparesis in Type 2 Diabetes: A pilot study
To determine the effect of soy germ pasta enriched in biologically active isoflavone aglycons on gastric emptying in type 2 diabetic patients with gastroparesis. This randomized double-blind, placebo-controlled study compared soy germ pasta with conventional pasta for effects on gastric emptying. Pa...
Saved in:
| Published in | Diabetes care Vol. 36; no. 11; pp. 3495 - 3497 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Alexandria, VA
American Diabetes Association
01.11.2013
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0149-5992 1935-5548 1935-5548 |
| DOI | 10.2337/dc12-1615 |
Cover
| Abstract | To determine the effect of soy germ pasta enriched in biologically active isoflavone aglycons on gastric emptying in type 2 diabetic patients with gastroparesis.
This randomized double-blind, placebo-controlled study compared soy germ pasta with conventional pasta for effects on gastric emptying. Patients (n = 10) with delayed gastric emptying consumed one serving per day of each pasta for 8 weeks, with a 4-week washout. Gastric emptying time (t1/2) was measured using the [(13)C]octanoic acid breath test at baseline and after each period, and blood glucose and insulin concentrations were determined after oral glucose load.
Soy germ pasta significantly accelerated the t1/2 in these patients (161.2 ± 17.5 min at baseline vs. 112.6 ± 11.2 min after treatment, P = 0.009). Such change differed significantly (P = 0.009) from that for conventional pasta (153.6 ± 24.2 vs. 156.2 ± 27.4 min), without affecting glucose or insulin concentrations.
These findings suggest that soy germ pasta may offer a simple dietary approach to managing diabetic gastropathy. |
|---|---|
| AbstractList | To determine the effect of soy germ pasta enriched in biologically active isoflavone aglycons on gastric emptying in type 2 diabetic patients with gastroparesis. This randomized double-blind, placebo-controlled study compared soy germ pasta with conventional pasta for effects on gastric emptying. Patients (n = 10) with delayed gastric emptying consumed one serving per day of each pasta for 8 weeks, with a 4-week washout. Gastric emptying time (t^sub 1/2^) was measured using the [^sup 13^C]octanoic acid breath test at baseline and after each period, and blood glucose and insulin concentrations were determined after oral glucose load. Soy germ pasta significantly accelerated the t^sub 1/2^ in these patients (161.2 ± 17.5 min at baseline vs. 112.6 ± 11.2 min after treatment, P = 0.009). Such change differed significantly (P = 0.009) from that for conventional pasta (153.6 ± 24.2 vs. 156.2 ± 27.4 min), without affecting glucose or insulin concentrations. These findings suggest that soy germ pasta may offer a simple dietary approach to managing diabetic gastropathy. To determine the effect of soy germ pasta enriched in biologically active isoflavone aglycons on gastric emptying in type 2 diabetic patients with gastroparesis.OBJECTIVETo determine the effect of soy germ pasta enriched in biologically active isoflavone aglycons on gastric emptying in type 2 diabetic patients with gastroparesis.This randomized double-blind, placebo-controlled study compared soy germ pasta with conventional pasta for effects on gastric emptying. Patients (n = 10) with delayed gastric emptying consumed one serving per day of each pasta for 8 weeks, with a 4-week washout. Gastric emptying time (t1/2) was measured using the [(13)C]octanoic acid breath test at baseline and after each period, and blood glucose and insulin concentrations were determined after oral glucose load.RESEARCH DESIGN AND METHODSThis randomized double-blind, placebo-controlled study compared soy germ pasta with conventional pasta for effects on gastric emptying. Patients (n = 10) with delayed gastric emptying consumed one serving per day of each pasta for 8 weeks, with a 4-week washout. Gastric emptying time (t1/2) was measured using the [(13)C]octanoic acid breath test at baseline and after each period, and blood glucose and insulin concentrations were determined after oral glucose load.Soy germ pasta significantly accelerated the t1/2 in these patients (161.2 ± 17.5 min at baseline vs. 112.6 ± 11.2 min after treatment, P = 0.009). Such change differed significantly (P = 0.009) from that for conventional pasta (153.6 ± 24.2 vs. 156.2 ± 27.4 min), without affecting glucose or insulin concentrations.RESULTSSoy germ pasta significantly accelerated the t1/2 in these patients (161.2 ± 17.5 min at baseline vs. 112.6 ± 11.2 min after treatment, P = 0.009). Such change differed significantly (P = 0.009) from that for conventional pasta (153.6 ± 24.2 vs. 156.2 ± 27.4 min), without affecting glucose or insulin concentrations.These findings suggest that soy germ pasta may offer a simple dietary approach to managing diabetic gastropathy.CONCLUSIONSThese findings suggest that soy germ pasta may offer a simple dietary approach to managing diabetic gastropathy. To determine the effect of soy germ pasta enriched in biologically active isoflavone aglycons on gastric emptying in type 2 diabetic patients with gastroparesis. This randomized double-blind, placebo-controlled study compared soy germ pasta with conventional pasta for effects on gastric emptying. Patients (n = 10) with delayed gastric emptying consumed one serving per day of each pasta for 8 weeks, with a 4-week washout. Gastric emptying time (t1/2) was measured using the [(13)C]octanoic acid breath test at baseline and after each period, and blood glucose and insulin concentrations were determined after oral glucose load. Soy germ pasta significantly accelerated the t1/2 in these patients (161.2 ± 17.5 min at baseline vs. 112.6 ± 11.2 min after treatment, P = 0.009). Such change differed significantly (P = 0.009) from that for conventional pasta (153.6 ± 24.2 vs. 156.2 ± 27.4 min), without affecting glucose or insulin concentrations. These findings suggest that soy germ pasta may offer a simple dietary approach to managing diabetic gastropathy. |
| Audience | Professional |
| Author | BATTEZZATI, Pier-Maria PERRIELLO, Gabriele ASCIUTTI, Stefania NARDI, Elisabetta CLERICI, Carlo SETCHELL, Kenneth D. R CASTELLANI, Danilo |
| Author_xml | – sequence: 1 givenname: Kenneth D. R surname: SETCHELL fullname: SETCHELL, Kenneth D. R organization: Department of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States – sequence: 2 givenname: Elisabetta surname: NARDI fullname: NARDI, Elisabetta organization: Clinic of Gastroenterology and Hepatology, University of Perugia, Perugia, Italy – sequence: 3 givenname: Pier-Maria surname: BATTEZZATI fullname: BATTEZZATI, Pier-Maria organization: Division of Internal Medicine, Department of Health Sciences, San Paolo School of Medicine, University of Milan, Milan, Italy – sequence: 4 givenname: Stefania surname: ASCIUTTI fullname: ASCIUTTI, Stefania organization: Clinic of Gastroenterology and Hepatology, University of Perugia, Perugia, Italy – sequence: 5 givenname: Danilo surname: CASTELLANI fullname: CASTELLANI, Danilo organization: Clinic of Gastroenterology and Hepatology, University of Perugia, Perugia, Italy – sequence: 6 givenname: Gabriele surname: PERRIELLO fullname: PERRIELLO, Gabriele organization: Department of Internal Medicine and Endocrine and Metabolic Sciences, University of Perugia, Perugia, Italy – sequence: 7 givenname: Carlo surname: CLERICI fullname: CLERICI, Carlo organization: Clinic of Gastroenterology and Hepatology, University of Perugia, Perugia, Italy |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27860580$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/23835688$$D View this record in MEDLINE/PubMed |
| BookMark | eNpt0k1rFDEYB_AgFbutHvwCEhDBy9S8T-JBWGq7FooK1vOQzTyzmzKTrMnMwn57s3S1VpYcEpJf_kkecoZOQgyA0GtKLhjn9YfWUVZRReUzNKOGy0pKoU_QjFBhKmkMO0VnOd8TQoTQ-gU6ZVxzqbSeofXXuIUe_4g7vIA04O82jxZfheTdGlrsA77JsevttpyY8XyA3sdkxzJeFJnixibIPu_h3W4DmOHP3i6hgI94jje-jyPO49TuXqLnne0zvDr05-jn9dXd5Zfq9tvi5nJ-W60EM2NlRddqKuslJc621kHdgTZGARXEdtLw2jGhRF13QirClBWEMkMcsUYuBTB-jj495G6m5QCtgzAm2zeb5Aebdk20vnm6Evy6WcVtwzVVWugS8P4QkOKvCfLYDD476HsbIE65oUJIQ5WhpNC3_9H7OKVQnrdXNaNcKf2oVraHxoculnPdPrSZc0k4F6pWRVVH1AoClEuW4ne-TD_xF0d8aS0M3h3d8ObfwvytyJ-_UMC7A7DZ2b5LNjifH12tFZGa8N-0dMFI |
| CODEN | DICAD2 |
| ContentType | Journal Article |
| Copyright | 2014 INIST-CNRS COPYRIGHT 2013 American Diabetes Association Copyright American Diabetes Association Nov 2013 2013 by the American Diabetes Association. 2013 |
| Copyright_xml | – notice: 2014 INIST-CNRS – notice: COPYRIGHT 2013 American Diabetes Association – notice: Copyright American Diabetes Association Nov 2013 – notice: 2013 by the American Diabetes Association. 2013 |
| DBID | IQODW CGR CUY CVF ECM EIF NPM K9. NAPCQ 7X8 5PM |
| DOI | 10.2337/dc12-1615 |
| DatabaseName | Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Premium MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Premium MEDLINE - Academic |
| DatabaseTitleList | ProQuest Health & Medical Complete (Alumni) MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1935-5548 |
| EndPage | 3497 |
| ExternalDocumentID | PMC3816848 3113666931 A350334676 23835688 27860580 |
| Genre | Randomized Controlled Trial Journal Article Feature |
| GroupedDBID | --- -ET ..I .55 .GJ .XZ 08P 0R~ 18M 29F 2WC 3O- 4.4 41~ 53G 5GY 5RE 5RS 5VS 6PF 7RV 7X2 7X7 88E 88I 8AF 8AO 8C1 8F7 8FE 8FH 8FI 8FJ 8G5 8R4 8R5 AAIKC AAKAS AAMNW AAQOH AAQQT AAWTL AAYEP AAYJJ ABOCM ABPPZ ABUWG ACGFO ACGOD ADBBV ADZCM AEGXH AENEX AERZD AFFNX AFKRA AFOSN AFRAH AHMBA AI. AIAGR ALIPV ALMA_UNASSIGNED_HOLDINGS AN0 AQUVI ATCPS AZQEC BAWUL BCR BCU BEC BENPR BHPHI BKEYQ BKNYI BLC BNQBC BPHCQ BTFSW BVXVI C1A CCPQU CS3 DIK DU5 DWQXO E3Z EBS EDB EJD EMOBN EX3 F5P FYUFA GNUQQ GUQSH GX1 H13 HCIFZ HMCUK HZ~ IAG IAO IEA IHR INH INR IOF IPO IQODW ITC J5H K9- KQ8 L7B M0K M0R M0T M1P M2O M2P M2Q M5~ N4W NAPCQ O5R O5S O9- OK1 OVD P2P PCD PEA PHGZT PQQKQ PROAC PSQYO Q2X RHI S0X SJFOW SV3 TDI TEORI TR2 TWZ UKHRP VH1 VVN W8F WH7 WHG WOQ WOW X7M YHG YOC ZCG ZGI ZXP ~KM AAFWJ CGR CUY CVF ECM EIF NPM PHGZM PJZUB PPXIY K9. 7X8 5PM |
| ID | FETCH-LOGICAL-g429t-a4fd8157b10cadace7fe8996e140af5937c246477f456026a401290c0a95b4e23 |
| ISSN | 0149-5992 1935-5548 |
| IngestDate | Thu Aug 21 18:09:58 EDT 2025 Fri Sep 05 12:59:21 EDT 2025 Mon Jun 30 16:49:01 EDT 2025 Tue Jun 17 20:16:15 EDT 2025 Thu Jun 12 23:49:50 EDT 2025 Tue Jun 10 20:44:38 EDT 2025 Mon Jul 21 06:02:38 EDT 2025 Wed Apr 02 07:25:19 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 11 |
| Keywords | Endocrinopathy Type 2 diabetes Human Nervous system diseases Gastrointestinal paresis Nutrition Motor system disorder Metabolic diseases Soybean Digestive diseases Intestinal disease Neurological disorder Endocrinology Gastric disease |
| Language | English |
| License | CC BY 4.0 Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-g429t-a4fd8157b10cadace7fe8996e140af5937c246477f456026a401290c0a95b4e23 |
| Notes | SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 14 ObjectType-Article-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3 |
| OpenAccessLink | https://pubmed.ncbi.nlm.nih.gov/PMC3816848 |
| PMID | 23835688 |
| PQID | 1447213668 |
| PQPubID | 47715 |
| PageCount | 3 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_3816848 proquest_miscellaneous_1445916910 proquest_journals_1447213668 gale_infotracmisc_A350334676 gale_infotracgeneralonefile_A350334676 gale_infotracacademiconefile_A350334676 pubmed_primary_23835688 pascalfrancis_primary_27860580 |
| PublicationCentury | 2000 |
| PublicationDate | 2013-11-01 |
| PublicationDateYYYYMMDD | 2013-11-01 |
| PublicationDate_xml | – month: 11 year: 2013 text: 2013-11-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | Alexandria, VA |
| PublicationPlace_xml | – name: Alexandria, VA – name: United States – name: Alexandria |
| PublicationTitle | Diabetes care |
| PublicationTitleAlternate | Diabetes Care |
| PublicationYear | 2013 |
| Publisher | American Diabetes Association |
| Publisher_xml | – name: American Diabetes Association |
| SSID | ssj0004488 |
| Score | 2.2172022 |
| Snippet | To determine the effect of soy germ pasta enriched in biologically active isoflavone aglycons on gastric emptying in type 2 diabetic patients with... |
| SourceID | pubmedcentral proquest gale pubmed pascalfrancis |
| SourceType | Open Access Repository Aggregation Database Index Database |
| StartPage | 3495 |
| SubjectTerms | Aged Biological and medical sciences Blood Glucose - drug effects Blood sugar Clinical trials Diabetes Diabetes Mellitus, Type 2 - complications Diabetes. Impaired glucose tolerance Diabetic Neuropathies - diet therapy Diet Diet therapy Double-Blind Method Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Food, Fortified Gastric Emptying - drug effects Gastroenterology. Liver. Pancreas. Abdomen Gastrointestinal diseases Gastroparesis - diet therapy Gastroparesis - etiology Glucose metabolism Humans Insulin - blood Isoflavones Isoflavones - administration & dosage Male Medical sciences Metabolic diseases Middle Aged Organic chemicals Original Research Other diseases. Semiology Pasta Pasta products Pilot Projects Soy Foods Soy products Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Type 2 diabetes |
| Title | Novel Soy Germ Pasta Enriched in Isoflavones Ameliorates Gastroparesis in Type 2 Diabetes: A pilot study |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/23835688 https://www.proquest.com/docview/1447213668 https://www.proquest.com/docview/1445916910 https://pubmed.ncbi.nlm.nih.gov/PMC3816848 |
| Volume | 36 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAFT databaseName: Colorado Digital library customDbUrl: eissn: 1935-5548 dateEnd: 20250401 omitProxy: true ssIdentifier: ssj0004488 issn: 0149-5992 databaseCode: KQ8 dateStart: 19780101 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries – providerCode: PRVAFT databaseName: Colorado Digital library customDbUrl: eissn: 1935-5548 dateEnd: 20250401 omitProxy: true ssIdentifier: ssj0004488 issn: 0149-5992 databaseCode: KQ8 dateStart: 20000101 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries – providerCode: PRVBFR databaseName: Free Medical Journals customDbUrl: eissn: 1935-5548 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0004488 issn: 0149-5992 databaseCode: DIK dateStart: 19780101 isFulltext: true titleUrlDefault: http://www.freemedicaljournals.com providerName: Flying Publisher – providerCode: PRVFQY databaseName: GFMER Free Medical Journals customDbUrl: eissn: 1935-5548 dateEnd: 20241001 omitProxy: true ssIdentifier: ssj0004488 issn: 0149-5992 databaseCode: GX1 dateStart: 20080101 isFulltext: true titleUrlDefault: http://www.gfmer.ch/Medical_journals/Free_medical.php providerName: Geneva Foundation for Medical Education and Research |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3di9NAEF_qCSKI-G31PFYQfQjRZrP5qG-HpxzKFcQ7uLey2Y9eoZeUa3ri_fXO7G7SpFRQX5aSnd2UzC-zM5uZ3xLyhiuV5lwmEORAwxlT4ZiLKJRc60IVKpbGZvlO0uMz_vU8OR8MfnarS-rivbzZWVfyP1qFa6BXrJL9B822k8IF-A36hRY0DO1f6XhSXetFsKp-BTMwsMFSgKsXgDCmdyKnUjBfVWYhrpGPPxCXeoH1-LjROgPJqwqTz5GPBFMd-zuxrgR6OV9UdYeA1vuwR812LWaNtTs0Vv29Wp_gaJONOEEg-jSyFQ6vNxsByPB5g9Wg1qOFZTo8ES752UERFul17Xp_1NqI0vf5vYoo9kV7dqlx9nUcAywSR67ZGGDHgNIALeqY05i7Ezi37TyLLVOAkhEL0WXtysATWl5ahYM3EiepOzVwi1S76bpFbrMsTfHoi2_fOzTzYNYcDRXe6UN7H6SO9iPbJfweKBdeJ-POQdkVqGzn23YcmNMH5L6PPOihg9FDMtDlI3LnxOdWPCYXFk0U0EQRTdSiiTZoovOSdtBEO2iiPTShIKKJMtqg6SMV1GKJWiw9IWdfPp9-Og79ORzhDLyVOhTcqDxKsiIaSaGE1JnREKanGoJzYRJwcCXjWNBswBuHmF5wu7spR2KcFFyz-CnZK-G_PSfURCbnBpzuDL_QR0JkMVORiopYZWMhzZC8w6c6RUXCo5LCF4nAaOQpmx7G-NkdFvd0SN72JGeOpX2X4H5PEMyn7HUf9BQ4XTqWlynLckwZGMH4RqNT_-6vIGDmGYviNM2H5HXbjVNjzmKpq7WVScbIRQVTPHMA2EzuUTQkWQ8arQCyvvd7yvmFZX_HL_05z1_8cc6X5O7m3dsne_XVWr8Cz7kuDizKfwPmdsjb |
| linkProvider | Colorado Alliance of Research Libraries |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Novel+soy+germ+pasta+enriched+in+isoflavones+ameliorates+gastroparesis+in+type+2+diabetes%3A+a+pilot+study&rft.jtitle=Diabetes+care&rft.au=Setchell%2C+Kenneth+D+R&rft.au=Nardi%2C+Elisabetta&rft.au=Battezzati%2C+Pier-Maria&rft.au=Asciutti%2C+Stefania&rft.date=2013-11-01&rft.eissn=1935-5548&rft.volume=36&rft.issue=11&rft.spage=3495&rft_id=info:doi/10.2337%2Fdc12-1615&rft_id=info%3Apmid%2F23835688&rft.externalDocID=23835688 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0149-5992&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0149-5992&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0149-5992&client=summon |