Novel Soy Germ Pasta Enriched in Isoflavones Ameliorates Gastroparesis in Type 2 Diabetes: A pilot study

To determine the effect of soy germ pasta enriched in biologically active isoflavone aglycons on gastric emptying in type 2 diabetic patients with gastroparesis. This randomized double-blind, placebo-controlled study compared soy germ pasta with conventional pasta for effects on gastric emptying. Pa...

Full description

Saved in:
Bibliographic Details
Published inDiabetes care Vol. 36; no. 11; pp. 3495 - 3497
Main Authors SETCHELL, Kenneth D. R, NARDI, Elisabetta, BATTEZZATI, Pier-Maria, ASCIUTTI, Stefania, CASTELLANI, Danilo, PERRIELLO, Gabriele, CLERICI, Carlo
Format Journal Article
LanguageEnglish
Published Alexandria, VA American Diabetes Association 01.11.2013
Subjects
Online AccessGet full text
ISSN0149-5992
1935-5548
1935-5548
DOI10.2337/dc12-1615

Cover

More Information
Summary:To determine the effect of soy germ pasta enriched in biologically active isoflavone aglycons on gastric emptying in type 2 diabetic patients with gastroparesis. This randomized double-blind, placebo-controlled study compared soy germ pasta with conventional pasta for effects on gastric emptying. Patients (n = 10) with delayed gastric emptying consumed one serving per day of each pasta for 8 weeks, with a 4-week washout. Gastric emptying time (t1/2) was measured using the [(13)C]octanoic acid breath test at baseline and after each period, and blood glucose and insulin concentrations were determined after oral glucose load. Soy germ pasta significantly accelerated the t1/2 in these patients (161.2 ± 17.5 min at baseline vs. 112.6 ± 11.2 min after treatment, P = 0.009). Such change differed significantly (P = 0.009) from that for conventional pasta (153.6 ± 24.2 vs. 156.2 ± 27.4 min), without affecting glucose or insulin concentrations. These findings suggest that soy germ pasta may offer a simple dietary approach to managing diabetic gastropathy.
Bibliography:SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 14
ObjectType-Article-1
ObjectType-Feature-2
content type line 23
ObjectType-Undefined-3
ISSN:0149-5992
1935-5548
1935-5548
DOI:10.2337/dc12-1615