Association between vitamin D deficiency and diabetic foot ulcer wound in diabetic subjects: A meta‐analysis

• Published in: International wound journal Vol. 20; no. 1; pp. 55 - 62
• Main Authors: Lin, Juan, Mo, Xinxin, Yang, Yejun, Tang, Chao, Chen, Jia
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.01.2023; John Wiley & Sons, Inc
• Subjects: Alfacalcidol; Analysis; Bias; Calcifediol; Diabetes; Diabetes Mellitus; Diabetic Foot; diabetic foot ulcer wound; Diet therapy; Foot diseases; Foot Ulcer - etiology; Humans; Influence; Leg ulcers; Meta-analysis; Original; Sensitivity analysis; severe; Statistical analysis; the prevalence of vitamin D deficiency; Vitamin D; Vitamin D deficiency; Vitamin D Deficiency - complications; Vitamin D Deficiency - epidemiology; vitamin D levels; Vitamin deficiency; Wound healing; China; India; the prevalence of vitamin D deficiency; diabetic foot ulcer wound; vitamin D deficiency; severe; vitamin D levels
• ISSN: 1742-4801; 1742-481X; 1742-481X
• DOI: 10.1111/iwj.13836

A meta‐analysis was performed to evaluate the association between vitamin D deficiency and diabetic foot ulcer wounds in diabetic subjects. A systematic literature search up to March 2022 incorporated 7586 subjects with diabetes mellitus at the beginning of the study; 1565 were using diabetic subjects with foot ulcer wounds, and 6021 were non‐ulcerated diabetic subjects. Statistical tools like the dichotomous and contentious method were used within a random or fixed‐influence model to establish the odds ratio (OR) and mean difference (MD) with 95% confidence intervals (CIs) to evaluate the influence of vitamin D deficiency in managing diabetic foot ulcer wound. Diabetic subjects with foot ulcer wounds had significantly lower vitamin D levels (MD, −6.48; 95% CI, −10.84 to −2.11, P < .004), higher prevalence of vitamin D deficiency (<50 nmoL/L) (OR, 1.82; 95% CI, 1.32‐2.52, P < .001), and higher prevalence of severe vitamin D deficiency (OR, 2.53; 95% CI, 1.65‐3.89, P < .001) compared with non‐ulcerated diabetic subjects. Diabetic subjects with foot ulcer wounds had significantly lower vitamin D levels, higher prevalence of vitamin D deficiency, and higher prevalence of severe vitamin D deficiency compared with non‐ulcerated diabetic subjects. Further studies are required to validate these findings.