Comparison of Serum Matrix Metalloproteinase-13 between Grade 3 and Grade 4 stages of Osteoarthritis

• Published in: Indian journal of clinical biochemistry Vol. 36; no. S1; p. S103
• Main Authors: Kumar, Purushottam, Kumari, Rekha, Shekhar, Ravi, Runu, Ritesh, Kumar, Santosh
• Format: Journal Article
• Language: English
• Published: Springer 24.05.2022
• Subjects: Comparative analysis; Osteoarthritis
• ISSN: 0970-1915

INTRODUCTION Osteoarthritis (OA) is the most common form of degenerative joint disease characterized by progressive degeneration of articular cartilage, osteophyte formation and joint space narrowing. Matrix metalloproteinases (MMP) are potential biomarkers for Osteoarthritis. Objective Comparison of serum Matrix Metalloproteinase (MMP) 13 level in Grade 3 and Grade 4 stages of osteoarthritis according to Kellgren and Lawrence, s system of classification. Materials and methods A total of 54 subjects were included, of them 28 patients were with Grade 3 and 26 patients with Grade 4 knee osteoarthritis according to Kellgren & Lawrence criteria, has been enrolled in study. Venous blood has been collected from all of them for estimation of MMP-13 by ELISA. Results The mean value of Grade 3 serum MMP-13 (1.176 [+ or -] 0.041) was found elevated compared to Grade 4 (0.993 [+ or -] 0.117). Mann-Whitney U-test was performed to compare these two groups and there was a significant difference between these two groups, (p < 0.05). Conclusion: After progression of osteoarthritis from Grade 3 to Grade 4 according to Kellgren and Lawrence system of classification, the value of serum MMP-13 level decrease. Keywords : Matrix metalloproteinase 13, Kellgren-Lawrence stage, Knee osteoarthritis, ELISA