Effects of Olopatadine Hydrochloride, a Histamine H1 Receptor Antagonist, on Histamine-Induced Skin Responses

Effects of olopatadine hydrochloride, a histamine H1 receptor antagonist, on histamine-induced skin responses were evaluated in 10 healthy subjects in comparison with placebo, fexofenadine hydrochloride, and bepotastine besilate. Olopatadine significantly suppressed histamine-induced wheal, flare, a...

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Published inDermatology Research and Practice Vol. 2010; no. 2010; pp. 1 - 4
Main Authors Ishii, Norito, Hashimoto, Takashi, Hamada, Takahiro, Dainichi, Teruki, Karashima, Tadashi, Nakama, Takekuni, Yasumoto, Shinichiro
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Puplishing Corporation 01.01.2010
Hindawi Publishing Corporation
Wiley
John Wiley & Sons, Inc
Subjects
Research Article
Online AccessGet full text
ISSN1687-6105
1687-6113
1687-6113
DOI10.1155/2010/638051

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Abstract Effects of olopatadine hydrochloride, a histamine H1 receptor antagonist, on histamine-induced skin responses were evaluated in 10 healthy subjects in comparison with placebo, fexofenadine hydrochloride, and bepotastine besilate. Olopatadine significantly suppressed histamine-induced wheal, flare, and itch, starting 30 minutes after oral administration. Olopatadine was more effective than fexofenadine and bepotastine. None of the drugs studied impaired performance of word processing tasks. These results suggest that olopatadine can suppress skin symptoms caused by histamine soon after administration.
AbstractList Effects of olopatadine hydrochloride, a histamine H1 receptor antagonist, on histamine-induced skin responses were evaluated in 10 healthy subjects in comparison with placebo, fexofenadine hydrochloride, and bepotastine besilate. Olopatadine significantly suppressed histamine-induced wheal, flare, and itch, starting 30 minutes after oral administration. Olopatadine was more effective than fexofenadine and bepotastine. None of the drugs studied impaired performance of word processing tasks. These results suggest that olopatadine can suppress skin symptoms caused by histamine soon after administration.
Author Dainichi, Teruki
Nakama, Takekuni
Hamada, Takahiro
Karashima, Tadashi
Yasumoto, Shinichiro
Hashimoto, Takashi
Ishii, Norito
AuthorAffiliation Department of Dermatology, Kurume University School of Medicine and Kurume University Institute of Cutaneous Cell Biology, 67 Asahimachi, Kurume, Fukuoka 830-0011, Japan
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  fullname: Yasumoto, Shinichiro
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Nakama, Takekuni
Hamada, Takahiro
Karashima, Tadashi
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Hashimoto, Takashi
Ishii, Norito
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Copyright Copyright © 2010 Takashi Hashimoto et al.
Copyright © 2010 Takashi Hashimoto et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright © 2010 Takashi Hashimoto et al. 2010
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Title Effects of Olopatadine Hydrochloride, a Histamine H1 Receptor Antagonist, on Histamine-Induced Skin Responses
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