Effects of Olopatadine Hydrochloride, a Histamine H1 Receptor Antagonist, on Histamine-Induced Skin Responses

Effects of olopatadine hydrochloride, a histamine H1 receptor antagonist, on histamine-induced skin responses were evaluated in 10 healthy subjects in comparison with placebo, fexofenadine hydrochloride, and bepotastine besilate. Olopatadine significantly suppressed histamine-induced wheal, flare, a...

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Published inDermatology Research and Practice Vol. 2010; no. 2010; pp. 1 - 4
Main Authors Ishii, Norito, Hashimoto, Takashi, Hamada, Takahiro, Dainichi, Teruki, Karashima, Tadashi, Nakama, Takekuni, Yasumoto, Shinichiro
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Puplishing Corporation 01.01.2010
Hindawi Publishing Corporation
Wiley
John Wiley & Sons, Inc
Subjects
Research Article
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ISSN1687-6105
1687-6113
1687-6113
DOI10.1155/2010/638051

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Summary:Effects of olopatadine hydrochloride, a histamine H1 receptor antagonist, on histamine-induced skin responses were evaluated in 10 healthy subjects in comparison with placebo, fexofenadine hydrochloride, and bepotastine besilate. Olopatadine significantly suppressed histamine-induced wheal, flare, and itch, starting 30 minutes after oral administration. Olopatadine was more effective than fexofenadine and bepotastine. None of the drugs studied impaired performance of word processing tasks. These results suggest that olopatadine can suppress skin symptoms caused by histamine soon after administration.
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Academic Editor: Thilo Gambichler
ISSN:1687-6105
1687-6113
1687-6113
DOI:10.1155/2010/638051