Biosynthesis of the methanogenic cofactors

• Published in: Cofactor Biosynthesis: a Mechanistic Perspective Vol. 61; pp. 299 - 337
• Main Author: White, Robert H
• Format: Book Chapter Journal Article
• Language: English
• Published: United States Elsevier Science & Technology 2001; Academic Press
• Subjects: Analytical, structural and metabolic biochemistry; Animal physiology; biochemical pathways; Biochemistry; Biological and medical sciences; biosynthesis; coenzymes; Coenzymes - biosynthesis; Coenzymes - metabolism; Coenzymes, vitamins; Endocrinology; Fundamental and applied biological sciences. Psychology; Furans - metabolism; Gene Expression Regulation, Archaeal; genes; Mesna - metabolism; methane; methane production; Methanococcus - genetics; Methanococcus - metabolism; Molecular Structure; Other biological molecules; Phosphothreonine - analogs & derivatives; Phosphothreonine - metabolism; Pterins - metabolism; Riboflavin - analogs & derivatives; Riboflavin - biosynthesis; Biosynthetic intermediate; Biosynthesis; Review; Coenzyme M; Cofactor; Methanogenic bacteria
• ISBN: 9780127098616; 0127098615
• ISSN: 0083-6729; 2162-2620
• DOI: 10.1016/S0083-6729(01)61010-0

Our current knowledge of the pathways and genes involved in the biosynthesis of the methanogenic coenzymes methanopterin, coenzyme B, methanofuran, coenzyme F 420, and coenzyme M is presented. Proposed reaction mechanisms for several of the novel reactions involved in the pathways are presented.