The anti-caries efficacy of a dentifrice containing 1.5% arginine and 1450 ppm fluoride as sodium monofluorophosphate assessed using Quantitative Light-induced Fluorescence (QLF)

• Published in: Journal of dentistry Vol. 41; pp. S22 - S28
• Main Authors: Yin, W, Hu, D.Y, Li, X, Fan, X, Zhang, Y.P, Pretty, I.A, Mateo, L.R, Cummins, D, Ellwood, R.P
• Format: Journal Article
• Language: English
• Published: England 01.08.2013
• Subjects: Adolescent; Arginine - therapeutic use; Calcium Carbonate - therapeutic use; Cariostatic Agents - therapeutic use; Child; Dental Caries - pathology; Dental Caries - prevention & control; Dental Enamel - drug effects; Dental Enamel - pathology; Dentifrices - therapeutic use; Dentistry; Double-Blind Method; Female; Fluorescence; Fluorides - therapeutic use; Follow-Up Studies; Humans; Image Processing, Computer-Assisted - methods; Light; Male; Phosphates - therapeutic use; Sodium Fluoride - therapeutic use; Tooth Remineralization - methods; Treatment Outcome; Caries; Fluoride; Arrest; Arginine; Enamel; Dentifrice; Reversal; Lesions
• ISSN: 0300-5712; 1879-176X; 1879-176X
• DOI: 10.1016/j.jdent.2010.04.004

Abstract Objective To compare the efficacy of a new dentifrice containing 1.5% arginine, an insoluble calcium compound and 1450 ppm fluoride to arrest and reverse naturally occurring buccal caries lesions in children relative to a positive control dentifrice containing 1450 ppm fluoride alone. Study design Participants from Chengdu, Sichuan Province, China tested three dentifrices: a new dentifrice containing 1.5% arginine, an insoluble calcium compound, and 1450 ppm fluoride, as sodium monofluorophosphate, a positive control dentifrice containing 1450 ppm fluoride, as sodium fluoride, in a silica base, and a matched negative control dentifrice without arginine and fluoride. Quantitative Light-induced Fluorescence (QLF) was used to assess buccal caries lesions at baseline and after 3 and 6 months of product use. Results 438 participants (initial age 9–13 years (mean 11.1 ± 0.78) and 48.6% female) completed the study. No adverse events attributable to the products were reported during the course of the study. The subject mean Δ Q (mm2 %), representing lesion volume, was 27.26 at baseline. After 6 months of product use, the Δ Q values for the arginine-containing, positive and negative control dentifrices were 13.46, 17.99 and 23.70 representing improvements from baseline of 50.6%, 34.0% and 13.1%. After 6 months product use, the differences between the pair wise comparisons for all three groups were statistically significant ( p < 0.01). The arginine-containing dentifrice demonstrated an improvement after only 3 months that was almost identical to that achieved by the conventional 1450 ppm fluoride dentifrice after 6 months. Conclusion The new dentifrice containing 1.5% arginine, an insoluble calcium compound, and 1450 ppm fluoride provides statistically significantly superior efficacy in arresting and reversing buccal caries lesions to a conventional dentifrice containing 1450 ppm fluoride alone.