Preparation of glucopyranosylamines in the pipeline reactor

Three kinds of glucopyranosylamines-N-(2-hydroxyethyl)-D-Glucopyranosylamine, N-butyl- beta -D-Gluco-pyranosylamine, and N-cyclohexyl- beta -D-Glucopyranosylamine were synthesized by using D-glucose and organic amines as raw materials in the pipeline reactor, and their yields were 94.3%, 98.1% and 9...

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Published inZhejiang da xue xue bao. Journal of Zhejiang University. Sciences edition. Li xue ban Vol. 36; no. 6; pp. 683 - 686
Main Authors Wang, Shuai, Qian, Chao, Liu, Zhen-Xing, Chen, Xin-Zhi
Format Journal Article
LanguageChinese
Published Zhejiang University Press 01.11.2009
Subjects
Color
Infrared radiation
Methyl alcohol
Pipelines
Raw materials
Reactors
Solvents
Synthesis
吡喃葡萄糖胺
管道化反应器
葡萄糖
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ISSN1008-9497
DOI10.3785/j.issn.1008-9497.2009.06.018

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Summary:Three kinds of glucopyranosylamines-N-(2-hydroxyethyl)-D-Glucopyranosylamine, N-butyl- beta -D-Gluco-pyranosylamine, and N-cyclohexyl- beta -D-Glucopyranosylamine were synthesized by using D-glucose and organic amines as raw materials in the pipeline reactor, and their yields were 94.3%, 98.1% and 95.7%, respectively. Moreover, with high purity and good color, the structure of the product was characterized by ESI-MS, IR and 1H-NMR. In addition, the synthesis of N-(2-hydroxyethyl)- beta -D-Glucopyranosylamine was mainly studied, the optimized conditions were: methanol/water solution as solvent, molar ratio of ethanolamine to D-glucose in 1.1, 70 degree C, and pressure of 1.0~2.0 MPa.
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ISSN:1008-9497
DOI:10.3785/j.issn.1008-9497.2009.06.018