HLA-DRB and HLA-DQB Allele and Haplotype Frequencies in Iranian Patients with Recurrent Aphthous Stomatitis

• Published in: Iranian journal of allergy, asthma, and immunology Vol. 15; no. 4; p. 289
• Main Authors: Najafi, Shamsolmoulouk, Mohammadzadeh, Mahsa, Zare Bidoki, Alireza, Meighani, Ghasem, Aslani, Saeed, Mahmoudi, Mahdi, Rezaei, Nima
• Format: Journal Article
• Language: English
• Published: Iran Tehran University of Medical Sciences 01.08.2016
• Subjects: Adult; Age; Allele frequency; Alleles; Antigens; Aphthous stomatitis; Cell adhesion & migration; Chronic illnesses; Confidence intervals; Disease; Female; Gene Frequency; Genes; Genetic Predisposition to Disease; Haplotype frequency; Haplotypes; Histocompatibility antigen HLA; HLA-DQ beta-Chains - genetics; HLA-DQ beta-Chains - immunology; HLA-DR beta-Chains - genetics; HLA-DR beta-Chains - immunology; Human leukocyte antigen; Humans; Male; Oral cavity; Patients; Population studies; Recurrent aphthous stomatitis; Stomatitis; Stomatitis, Aphthous - epidemiology; Stomatitis, Aphthous - genetics; Stomatitis, Aphthous - immunology; Studies; Susceptibility; Tumor necrosis factor-TNF; Recurrent aphthous stomatitis; Haplotype frequency; Allele frequency; Human leukocyte antigen
• ISSN: 1735-1502; 1735-5249

Recurrent aphthous stomatitis (RAS) is known as the most common chronic disease of the oral cavity, which affects a range of 5-25% of the population. RAS appears to be associated with some human leukocyte antigen (HLA) class II alleles and haplotypes. This study attempts to survey the distribution of HLA-DRB and -DQB alleles among Iranian RAS patients and healthy controls. In order to evaluate the association of HLA-DR and DQ alleles and haplotypes, 54 patients with RAS and 100 unrelated healthy subjects as control group were investigated. Our data indicated that DRB1*13:17, DRB1*15:01, and DRB5*01 were significantly more frequent in RAS patients in comparison to controls. However, DRB3:01allele frequency was higher in the controls compared to the patients. The significantly frequent allele in the patients compared with the healthy subjects was HLA-DQB1*03:02. However, both HLA-DQB1*02:01 and HLA-DQB1*03:01 alleles were most frequent in the healthy individuals rather than the patients. The DRB*04/DQB1*03:01 and DRB*01:01/DQB1*02:01 haplotypes were significantly distributed in healthy subjects compared with patients. However, DRB*07:01/DQB1*03:02 haplotype was found to be significantly frequent in patients than controls. In respect of HLA genes, factors are involved in the incidence of RAS; various HLA-DRB and HLA-DQB1 alleles and the related haplotypes are suggested to be the three main RAS susceptibility factors in our population study.