Alzheimer's disease treatment: The share of herbal medicines

• Published in: Iranian journal of basic medical sciences Vol. 24; no. 2; pp. 123 - 135
• Main Authors: Soheili, Masoud, Karimian, Mohammad, Hamidi, Gholamali, Salami, Mahmoud
• Format: Journal Article
• Language: English
• Published: Iran Mashhad University of Medical Sciences 01.02.2021
• Subjects: Alzheimer's disease; crocus sativus; ginkgo biloba; ginseng; Herbal medicine; lavandula angustifolia; magnolia officinalis; melissa officinalis; Neurological disorders; Review; salvia miltiorrhiza; Ginkgo biloba; Salvia miltiorrhiza; Alzheimer’s disease; Crocus sativus; Lavandula angustifolia; Magnolia officinalis; Melissa officinalis; Ginseng
• ISSN: 2008-3866; 2008-3874
• DOI: 10.22038/IJBMS.2020.50536.11512

One of the most frequent forms of dementia in neurological disorders is Alzheimer's disease (AD). It is a chronic neurodegenerative disease characterized by impaired learning and memory. Pathological symptoms as extracellular amyloid-beta (Aβ) plaques and intracellular accumulation of neurofibrillary tangles occur in AD. Due to the aging of the population and increased prevalence of AD, discovery of new therapeutic agents with the highest effectiveness and fewer side effect seems to be necessary. Numerous synthetic medicines such as tacrine, donepezil, galantamine, rivastigmine, memantine, glutathione, ascorbic acid, ubiquinone, ibuprofen, and ladostigil are routinely used for reduction of the symptoms and prevention of disease progression. Nowadays, herbal medicines have attracted popular attention for numerous beneficial effects with little side effects. , and have been widely used for relief of symptoms of some neurological disorders. This paper reviews the therapeutic effects of phytomedicines with prominent effects against various factors implicated in the emergence and progression of AD.