Neuroinflammation: 2022 update

Besides important progress in the understanding of the pathological substrate of COVID-19-associated brain disease, major insights into mechanisms of neurodegeneration in human disease have been provided in neuropathological studies published in 2021. Recently developed techniques, which allow the s...

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Bibliographic Details
Published inFree Neuropathology Vol. 3; p. 3
Main Author Lassmann, Hans
Format Journal Article
LanguageEnglish
Published Germany freeneuropathology 01.01.2022
University of Münster / Open Journals System
Subjects
Alzheimer’s disease
COVID-19
Microglia
Multiple sclerosis
Neurodegeneration
Review
COVID-19
Multiple sclerosis
Alzheimer’s disease
Neurodegeneration
Microglia
Online AccessGet full text
ISSN2699-4445
2699-4445
DOI10.17879/freeneuropathology-2022-3790

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Summary:Besides important progress in the understanding of the pathological substrate of COVID-19-associated brain disease, major insights into mechanisms of neurodegeneration in human disease have been provided in neuropathological studies published in 2021. Recently developed techniques, which allow the simultaneous detection of a large battery of different molecules within single cells, have proven useful in the analysis of disease mechanisms in experimental and human neuroinflammatory conditions. They have elucidated protective and detrimental effects of activated microglia, which act in a stage and context-dependent manner in the induction and propagation of neurodegeneration. In addition, they emphasize the importance of synaptic damage and of selective neuronal vulnerability in the respective diseases. The results provide important new insights with high clinical relevance.
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ISSN:2699-4445
2699-4445
DOI:10.17879/freeneuropathology-2022-3790