Single nucleotide polymorphisms in ABCG5 and ABCG8 are associated with changes in cholesterol metabolism during weight losss

The purpose of this study was to examine whether changes in cholesterol metabolism after weight loss were affected by single nucleotide polymorphisms (SNPs) in ABCG5 and ABCG8 genes. Thirty-five hypercholesterolemic women lost 11.7 ± 2.5 kg (P < 0.001). Cholesterol kinetics were assessed using st...

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Published inJournal of lipid research Vol. 48; no. 12; pp. 2607 - 2613
Main Authors Santosa, Sylvia, Demonty, Isabelle, Lichtenstein, Alice H., Ordovas, Jose M., Jones, Peter J.H.
Format Journal Article
LanguageEnglish
Published Elsevier Inc 01.12.2007
Elsevier
Subjects
diet
genetics
hypercholesterolemic
lipids
metabolism
mutations
obesity
overweight
physical activity
women
lipids
genetics
mutations
hypercholesterolemic
metabolism
diet
overweight
obesity
women
physical activity
Online AccessGet full text
ISSN0022-2275
1539-7262
DOI10.1194/jlr.M600452-JLR200

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Summary:The purpose of this study was to examine whether changes in cholesterol metabolism after weight loss were affected by single nucleotide polymorphisms (SNPs) in ABCG5 and ABCG8 genes. Thirty-five hypercholesterolemic women lost 11.7 ± 2.5 kg (P < 0.001). Cholesterol kinetics were assessed using stable isotope techniques. TaqMan PCR was used to detect SNPs in ABCG5/G8. Homozygous Q604E variants in ABCG5 had larger (P < 0.05) reductions in cholesterol absorption and greater increases (P < 0.05) in synthesis in contrast to heterozygous and homozygous wild-type carriers. Heterozygous C54Y carriers had smaller declines (P = 0.047) in synthesis compared with homozygous variant individuals. The presence of at least one Y54 variant was associated with higher (P = 0.042) post-weight-loss synthesis compared with carriers of the C54 genotype. The direction of the results is consistent with cross-sectional studies on the effects of Q604E and C54Y polymorphisms on plasma cholesterol. SNPs in ABCG5/G8 were found to be associated with the response of cholesterol metabolism to weight loss. The evidence for associations between SNPs in ABCG5/G8 and various parameters of cholesterol metabolism indicates the potential effectiveness of establishing genetic screening tools to determine optimal lipid-lowering treatment routes for individuals during weight reduction.
ISSN:0022-2275
1539-7262
DOI:10.1194/jlr.M600452-JLR200