Application of a New Method of Noninvasive Aassessment of Carbohydrate Metabolism Disorders in the Population Screening

• Published in: Trudy Instituta sistemnogo programmirovaniâ Vol. 32; no. 5; pp. 121 - 130
• Main Authors: Berezin, Andrey Aleksandrovich, Novikov, Roman Sergeevich, Novopashin, Maxim Aleksandrovich, Pozin, Boris Aronovich, Shmid, Alexander Viktorovich
• Format: Journal Article
• Language: English
• Published: 2020
• ISSN: 2079-8156; 2220-6426
• DOI: 10.15514/ISPRAS-2020-32(5)-9

Method for conducting a non-invasive screening of the population for carbohydrate metabolism disorders (CMD) has been developed and described. The novelty of the method is that there are no medical standards in the field of endocrinology for the non-invasive type of screening, so the method was based on the results of a clinical study of electrocardiographic abnormalities in patients with CMD, where the method of non-invasive determination of CMD by first-lead ECG was used. During the development of the method, an additional analysis of the ECG sample obtained during the study was performed. As a result of the analysis, it was concluded that the effectiveness of the method (sensitivity and specificity) vary slightly depending on the time of taking an ECG during the day. This means that the patient can come to the screening using the new method of non-invasive detection of CMD not only in the morning and not necessarily on an empty stomach, in contrast to the invasive methods (fasting plasma glucose test and oral glucose tolerance test). To make a decision «there is a suspicion of CMD /there is no suspicion of CMD», the patient only needs to take up to 2 ECGs.