A Novel Neuropathological Subtype of Amyotrophic Lateral Sclerosis Characterised by Prominent Astroglial TDP‐43 Pathology

This study identified a novel amyotrophic lateral sclerosis subtype with prominent astroglial phosphorylated TDP‐43 inclusions and minimal neuronal inclusions. The patients shared a clinical phenotype of flail arm variant of ALS. These observations suggest a more critical role for astroglia than pre...

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Published inNeuropathology and applied neurobiology Vol. 51; no. 5; p. e70036
Main Authors Matsubara, Tomoyasu, Izumi, Yuishin, Hatanaka, Yuki, Takahara, Mika, Kondo, Amuro, Matsukura, Kiyoshi, Arakawa, Akira, Haga, Toshihiro, Miyamoto, Ryosuke, Naruse, Hiroya, Morino, Hiroyuki, Toda, Tatsushi, Murayama, Shigeo, Saito, Yuko
Format Journal Article
LanguageEnglish
Published England 01.10.2025
Subjects
flail arm syndrome
motor neuron disease
TDP‐43
amyotrophic lateral sclerosis
astrocyte
autopsy
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ISSN0305-1846
1365-2990
1365-2990
DOI10.1111/nan.70036

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Summary:This study identified a novel amyotrophic lateral sclerosis subtype with prominent astroglial phosphorylated TDP‐43 inclusions and minimal neuronal inclusions. The patients shared a clinical phenotype of flail arm variant of ALS. These observations suggest a more critical role for astroglia than previously recognised.
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ISSN:0305-1846
1365-2990
1365-2990
DOI:10.1111/nan.70036