LIPID PEROXIDATION AND ANTIOXIDANT DEFENSE INDICES IN LIVER TISSUE OF RATS FOLLOWING EXPERIMENTAL SURGICAL TRAUMA AND POST-TRAUMATIC STRESS DISORDER

This study investigated changes in the concentration of secondary lipid peroxidation (LPO) products and the state of antioxidant defense in liver tissue of rats exposed to surgical trauma reproduced under experimental post-traumatic stress disorder (PTSD). The series of experiments were conducted on...

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Published inАктуальні проблеми сучасної медицини Вісник Української медичної стоматологічної академії Vol. 25; no. 2; pp. 160 - 163
Main Authors Riabushko, R.M., Kostenko, V.O.
Format Journal Article
LanguageEnglish
Published 29.05.2025
Online AccessGet full text
ISSN2077-1096
2077-1126
2077-1126
DOI10.31718/2077-1096.25.2.166

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Abstract This study investigated changes in the concentration of secondary lipid peroxidation (LPO) products and the state of antioxidant defense in liver tissue of rats exposed to surgical trauma reproduced under experimental post-traumatic stress disorder (PTSD). The series of experiments were conducted on 42 male Wistar rats weighing 210–230 g, divided into six groups: Group 1 included intact animals; Group 2 involved animals subjected to a single prolonged stress (SPS) model of PTSD; Group 3 included sham-operated animals; Group 4 consisted of animals subjected to laparotomy; Group 5 involved animals exposed to SPS followed by sham surgery; Group 6 included animals subjected to laparotomy under modeled PTSD. The concentration of secondary LPO products in liver homogenates was measured spectrophotometrically. The findings showed that SPS induced activation of LPO processes in the liver, manifested by an increase in secondary LPO products and a decrease in antioxidant defense efficiency. Surgical trauma in the form of laparotomy led to a significant enhancement of free radical oxidation in liver tissue; however, these changes were less pronounced compared to the group exposed to the combined effects of surgical and psychoemotional stress. The combination of surgical trauma and PTSD resulted in the highest levels of LPO in liver tissue, indicating a synergistic effect of both pathogenic factors on cellular damage and depletion of antioxidant protection. These findings highlight the need for further research aimed at developing therapeutic strategies focused on redox regulation and the prevention of metabolic complications associated with the combined effects of PTSD and surgical stress.
AbstractList This study investigated changes in the concentration of secondary lipid peroxidation (LPO) products and the state of antioxidant defense in liver tissue of rats exposed to surgical trauma reproduced under experimental post-traumatic stress disorder (PTSD). The series of experiments were conducted on 42 male Wistar rats weighing 210–230 g, divided into six groups: Group 1 included intact animals; Group 2 involved animals subjected to a single prolonged stress (SPS) model of PTSD; Group 3 included sham-operated animals; Group 4 consisted of animals subjected to laparotomy; Group 5 involved animals exposed to SPS followed by sham surgery; Group 6 included animals subjected to laparotomy under modeled PTSD. The concentration of secondary LPO products in liver homogenates was measured spectrophotometrically. The findings showed that SPS induced activation of LPO processes in the liver, manifested by an increase in secondary LPO products and a decrease in antioxidant defense efficiency. Surgical trauma in the form of laparotomy led to a significant enhancement of free radical oxidation in liver tissue; however, these changes were less pronounced compared to the group exposed to the combined effects of surgical and psychoemotional stress. The combination of surgical trauma and PTSD resulted in the highest levels of LPO in liver tissue, indicating a synergistic effect of both pathogenic factors on cellular damage and depletion of antioxidant protection. These findings highlight the need for further research aimed at developing therapeutic strategies focused on redox regulation and the prevention of metabolic complications associated with the combined effects of PTSD and surgical stress.
Author Riabushko, R.M.
Kostenko, V.O.
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Cites_doi 10.3390/biom11091365
10.31718/mep.2023.27.5-6.04
10.31718/2077-1096.23.3.137
10.3389/fphar.2017.00615
10.15407/fz68.03.035
10.1016/j.bbrc.2023.149167
10.3390/biom13091291
10.1007/s00406-015-0638-5
10.1016/j.heliyon.2023.e15551
10.1111/acps.13529
10.3390/ijerph20042937
10.3389/fpsyt.2021.707543
10.31718/2077-1096.24.2.137
10.1016/j.neuroscience.2013.01.040
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Title LIPID PEROXIDATION AND ANTIOXIDANT DEFENSE INDICES IN LIVER TISSUE OF RATS FOLLOWING EXPERIMENTAL SURGICAL TRAUMA AND POST-TRAUMATIC STRESS DISORDER
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