Human Neuroblasts Migrate to the Olfactory Bulb via a Lateral Ventricular Extension

• Published in: Science (American Association for the Advancement of Science) Vol. 315; no. 5816; pp. 1243 - 1249
• Main Authors: Curtis, Maurice A, Kam, Monica, Nannmark, Ulf, Anderson, Michelle F, Axell, Mathilda Zetterstrom, Wikkelso, Carsten, Holtås, Stig, van Roon-Mom, Willeke M.C, Björk-Eriksson, Thomas, Nordborg, Claes, Frisén, Jonas, Dragunow, Michael, Faull, Richard L.M, Eriksson, Peter S
• Format: Journal Article
• Language: English
• Published: Washington, DC American Association for the Advancement of Science 02.03.2007; The American Association for the Advancement of Science
• Subjects: adults; analysis; anatomy & histology; Apoptosis; Basic Helix-Loop-Helix Transcription Factors; Basic Helix-Loop-Helix Transcription Factors - genetics; Biological and medical sciences; Brain; Bulbs; Cell adhesion & migration; Cell Differentiation; Cell growth; Cell Movement; Cell Nucleus; Cell Nucleus - chemistry; Cell Nucleus - ultrastructure; Cell Shape; chemistry; Clinical Medicine; cytology; Electron; electron microscopy; Ependyma; Ependyma - cytology; Eye Proteins; Eye Proteins - genetics; Forebrain; Fundamental and applied biological sciences. Psychology; genetics; Histology; Homeodomain Proteins; Homeodomain Proteins - genetics; Human; Humans; Klinisk medicin; Lateral Ventricles; Lateral Ventricles - anatomy & histology; Lateral Ventricles - cytology; Magnetic Resonance Imaging; Markers; Medical and Health Sciences; Medicin och hälsovetenskap; Microscopy; Microscopy, Electron; Microtubule-Associated Proteins; Microtubule-Associated Proteins - genetics; migratory behavior; Nerve Tissue Proteins; Nerve Tissue Proteins - genetics; Nervous system; Neural Cell Adhesion Molecule L1; Neural Cell Adhesion Molecule L1 - analysis; Neural stem cells; Neuroblasts; Neurons; Neurons - chemistry; Neurons - cytology; Neurons - physiology; Neurons - ultrastructure; Neuropeptides; Neuropeptides - genetics; Neuroscience; NMR; Nuclear magnetic resonance; Olfactory Bulb; Olfactory Bulb - anatomy & histology; Olfactory Bulb - cytology; Olfactory Pathways; Olfactory Pathways - anatomy & histology; Olfactory Pathways - cytology; Olfactory system and olfaction. Gustatory system and gustation; Oligodendrocyte Transcription Factor 2; Paired Box Transcription Factors; Paired Box Transcription Factors - genetics; PAX6 Transcription Factor; physiology; Progenitor cells; Prosencephalon; Prosencephalon - anatomy & histology; Prosencephalon - cytology; Repressor Proteins; Repressor Proteins - genetics; Rodents; Sialic Acids; Sialic Acids - analysis; Signal transduction; Smell; Stem Cells; Stem Cells - chemistry; Stem Cells - cytology; Stem Cells - physiology; Stem Cells - ultrastructure; Streams; Tubulin; Tubulin - analysis; ultrastructure; Vertebrates: nervous system and sense organs; Human; Central nervous system; Precursor cell; Rodentia; Electron microscopy; Neuroblast; Nuclear magnetic resonance imaging; Encephalon; Vertebrata; Mammalia; Olfactory pathway; Neuron; Olfactory bulb
• ISSN: 0036-8075; 1095-9203; 1095-9203
• DOI: 10.1126/science.1136281

The rostral migratory stream (RMS) is the main pathway by which newly born subventricular zone cells reach the olfactory bulb (OB) in rodents. However, the RMS in the adult human brain has been elusive. We demonstrate the presence of a human RMS, which is unexpectedly organized around a lateral ventricular extension reaching the OB, and illustrate the neuroblasts in it. The RMS ensheathing the lateral olfactory ventricular extension, as seen by magnetic resonance imaging, cell-specific markers, and electron microscopy, contains progenitor cells with migratory characteristics and cells that incorporate 5-bromo-2'-deoxyuridine and become mature neurons in the OB.