Surface coating with pharmacological molecules

• Published in: Indian journal of physiology and pharmacology pp. 1 - 11
• Main Authors: Frumento, Davide, Țălu, Ștefan
• Format: Journal Article
• Language: English
• Published: 25.08.2025
• ISSN: 0019-5499; 2582-2799
• DOI: 10.25259/IJPP_88_2025

The application of pharmacological molecules in surface coatings has emerged as an innovative approach to enhance the effectiveness and safety of surgical procedures. This review outlines the concept and potential uses of pharmacologically coated surfaces in surgical settings. By applying a thin layer of bioactive compounds to surgical implants or devices, these coatings provide a comprehensive strategy to tackle issues such as infection control, implant integration and tissue regeneration. Various techniques, including physical and chemical vapour deposition as well as electrospinning, can be utilised to achieve precise management of drug release rates and coating durability. In fields such as orthopaedics, cardiovascular surgery and plastic surgery, pharmacologically coated surfaces show significant promise in enhancing biocompatibility, minimising infection risks and facilitating tissue healing. However, the use of pharmacological coatings also presents several challenges and considerations. It is crucial to ensure the long-term stability and effectiveness of these coatings, as variations in drug release rates may affect therapeutic results. In addition, compatibility with current surgical materials and methods must be assessed to guarantee smooth integration into clinical practice. Addressing issues such as long-term stability, material compatibility, and regulatory requirements is essential for the successful implementation of this technology in clinical settings.