Objectively Measured Physical Activity and Fat Mass in Children: A Bias-Adjusted Meta-Analysis of Prospective Studies

• Published in: PloS one Vol. 6; no. 2; p. e17205
• Main Authors: Wilks, Desiree C., Sharp, Stephen J., Ekelund, Ulf, Thompson, Simon G., Mander, Adrian P., Turner, Rebecca M., Jebb, Susan A., Lindroos, Anna Karin
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 23.02.2011; Public Library of Science (PLoS)
• Subjects: Adipose Tissue - anatomy & histology; Adipose Tissue - metabolism; Adiposity - physiology; Analysis; Bias; Body Composition - physiology; Body fat; Body weight gain; Check lists; Child; Child, Preschool; Children; Cognitive biases; Collaboration; Correlation; Correlation analysis; Correlation coefficient; Correlation coefficients; Councils; Data Interpretation, Statistical; Epidemiology; Exercise; Female; Health care; Heart rate; Heterogeneity; Humans; Male; Medical research; Medicine; Meta-analysis; Methods; Motor Activity - physiology; Nutrition research; Obesity; Obesity - epidemiology; Organ Size; Physical activity; Prevention; Prospective Studies; Public health; Research Design - statistics & numerical data; Source studies; Water measurement; Weight control; Weight Gain - physiology; Weight gain measurement
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0017205

Studies investigating the prevention of weight gain differ considerably in design and quality, which impedes pooling them in conventional meta-analyses, the basis for evidence-based policy making. This study is aimed at quantifying the prospective association between measured physical activity and fat mass in children, using a meta-analysis method that allows inclusion of heterogeneous studies by adjusting for differences through eliciting and incorporating expert opinion. Studies on prevention of weight gain using objectively measured exposure and outcome were eligible; they were adopted from a recently published systematic review. Differences in study quality and design were considered as internal and external biases and captured in checklists. Study results were converted to correlation coefficients and biases were considered either additive or proportional on this scale. The extent and uncertainty of biases in each study were elicited in a formal process by six quantitatively-trained assessors and five subject-matter specialists. Biases for each study were combined across assessors using median pooling. Results were combined across studies by random-effects meta-analysis. The combined correlation of the unadjusted results from the six studies was -0.04 (95%CI: -0.22, 0.14) with considerable heterogeneity (I² = 78%), which makes it difficult to interpret the result. After bias-adjustment the pooled correlation was -0.01 (95%CI: -0.18, 0.16) with apparent study compatibility (I² = 0%). By using this method the prospective association between physical activity and fat mass could be quantitatively synthesized; the result suggests no association. Objectively measured physical activity may not be the key determinant of unhealthy weight gain in children.