Mechanism of Forelimb Motor Function Restoration after Cervical Spinal Cord Hemisection in Rats: A Comparison of Juveniles and Adults

• Published in: Behavioural Neurology Vol. 2016; no. 2016; pp. 1 - 9
• Main Authors: Ichimura, Shoichi, Takeuchi, Takumi, Ohne, Hideaki, Satomi, Kazuhiko, Takahashi, Masahito, Hasegawa, Atsushi, Sato, Shunsuke
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2016; Hindawi Limited; John Wiley & Sons, Inc; Wiley
• Subjects: Age Factors; Animals; Cervical Vertebrae; Comparative analysis; Disease Models, Animal; Forelimb; Forelimb - innervation; Forelimb - metabolism; Forelimb - physiology; Male; Minors; Motor Activity; Motor Activity - physiology; Neurosciences. Biological psychiatry. Neuropsychiatry; Paralysis; Rats; Rats, Wistar; RC321-571; Recovery of Function; Research Article; Rodents; Spinal Cord; Spinal Cord Injuries; Spinal Cord Injuries - rehabilitation; Spinal Cord Injuries - therapy; Stem cells; Studies; Upper Extremity; Upper Extremity - physiopathology
• ISSN: 0953-4180; 1875-8584; 1875-8584
• DOI: 10.1155/2016/1035473

The aim of this study was to investigate forelimb motor function after cervical spinal cord injury in juvenile and adult rats. Both rats received a left segmental hemisection of the spinal cord after C3-C4 laminectomy. Behavioral evaluation of motor function was monitored and assessed using the New Rating Scale (NRS) and Forelimb Locomotor Scale (FLS) and by measuring the range of motion (ROM) of both the elbow and wrist. Complete left forelimb motor paralysis was observed in both rats. The NRS showed motor function recovery restored to 50.2±24.7% in juvenile rats and 34.0±19.8% in adult rats. FLS was 60.4±26.8% in juvenile rats and 46.5±26.9% in adult rats. ROM of the elbow and wrist were 88.9±20.6% and 44.4±24.1% in juvenile rats and 70.0±29.2% and 40.0±21.1% in adult rats. Thus, the NRS and ROM of the elbow showed a significant difference between age groups. These results indicate that left hemisection of the cervical spinal cord was not related to right-sided motor functions. Moreover, while motor paralysis of the left forelimb gradually recovered in both groups, the improvement was greater in juvenile rats.