Involvement of extracellular signal-regulated kinase in nobiletin-induced melanogenesis in murine B16/F10 melanoma cells

• Published in: Bioscience, biotechnology, and biochemistry Vol. 71; no. 7; pp. 1781 - 1784
• Main Authors: Yoon, H.S.(Cheju National Univ., Jeju (Korea R.)), Lee, S.R, Ko, H.C, Choi, S.Y, Park, J.G, Kim, J.K, Kim, S.J
• Format: Journal Article
• Language: English
• Published: Tokyo Japan Society for Bioscience, Biotechnology, and Agrochemistry 01.07.2007; Japan Society for Bioscience Biotechnology and Agrochemistry; Oxford University Press
• Subjects: Animals; Biological and medical sciences; biotechnology; Cell Line, Tumor; CITRUS; extracellular signal-regulated kinase (ERK); Extracellular Signal-Regulated MAP Kinases - physiology; Flavones - physiology; FLAVONOIDE; FLAVONOIDES; FLAVONOIDS; Flavonoids - physiology; Fundamental and applied biological sciences. Psychology; MEDICINAL PROPERTIES; melanin; MELANINAS; MELANINE; MELANINS; Melanins - biosynthesis; melanogenesis; MELANOMA; Melanoma, Experimental - enzymology; Melanoma, Experimental - etiology; MELANOME; Mice; mitogen-activated protein kinase; Monophenol Monooxygenase - physiology; nobiletin; OXIDOREDUCTASES; OXIDORREDUCTASAS; OXYDOREDUCTASE; PROPIEDADES MEDICINALES; PROPRIETE PHARMACOLOGIQUE; tyrosinase; nobiletin; Extracellular signal-regulated protein kinase; Enzyme; Rodentia; Melanoma; melanogenesis; Monophenol monooxygenase; tyrosinase; extracellular signal-regulated kinase (ERK); Vertebrata; Mammalia; Mouse; Oxidoreductases
• ISSN: 0916-8451; 1347-6947; 1347-6947
• DOI: 10.1271/bbb.70088

Nobiletin contributes to pharmacological activities such as anti-cancer and anti-inflammatory effects, but little is known about its effect on melanogenesis. In this study, we found that nobiletin increased melanin content and tyrosinase activity in murine B16/F10 melanoma cells. Furthermore, inhibition of the extracellular signal-regulated kinase (ERK) pathway with U0216 resulted in inhibition of nobiletin-induced melanin synthesis and tyrosinase expression.