Further Studies in Tissue Homotransplantation in Cattle

• Published in: Development (Cambridge) Vol. 5; no. 4; pp. 351 - 367
• Main Authors: Billingham, R. E., Lampkin, G. H.
• Format: Journal Article
• Language: English
• Published: Oxford University Press for The Company of Biologists Limited 01.12.1957
• ISSN: 0950-1991; 1477-9129
• DOI: 10.1242/dev.5.4.351

The work which forms the subject-matter of this communication is mainly complementary to that reported upon previously (see Anderson, Billingham, Lampkin, & Medawar, 1951; Billingham, Lampkin, Medawar, & Williams, 1952). It may be recalled that these transplantation studies were initiated in the mistaken belief that the one- or two-egg origin of twins in cattle could be established unequivocally according to the fate of skin grafts mutually exchanged between them, as it can in man (Rogers & Allen, 1955; Snyderman, Rogers, & Allen, 1956). In the event it proved otherwise, for although cattle reacted against and destroyed with great promptitude skin homografts from unrelated individuals, or even from full siblings of separate birth or from their dams, skin grafts exchanged between dizygotic twins nearly always proved to be almost as acceptable as those exchanged between monozygotic twins.