Standardizing the reporting of Mendelian randomization studies

• Published in: BMC medicine Vol. 21; no. 1; pp. 187 - 3
• Main Authors: Au Yeung, Shiu Lun, Gill, Dipender
• Format: Journal Article
• Language: English
• Published: London BioMed Central 18.05.2023; BioMed Central Ltd; BMC
• Subjects: Alzheimer's disease; Analysis; Biomedicine; Checklist; Clinical trials; Commentary; Epidemiology; Genetic variation; Genome-wide association studies; Genomes; Health policy; Humans; Medicine; Medicine & Public Health; Mendelian randomization; Mendelian Randomization Analysis; Methods; Proteins; Public health; Randomization; Reporting; Risk Factors; Selection bias; STROBE-MR; Triangulation; United Kingdom; Checklist; STROBE-MR; Mendelian randomization; Reporting
• ISSN: 1741-7015; 1741-7015
• DOI: 10.1186/s12916-023-02894-8

[...]the STROBE-MR checklist (https://www.strobe-mr.org/) has been developed to help authors ensure reporting of all the details essential for evaluating the quality and validity of an MR study [2]. [...]this form of MR requires reporting of additional information, such as clear description of the gene region, the trait used to identify genetic instruments, corresponding MR methods, and whether the analysis was corroborated with colocalization analyses [6]. Via triangulation of evidence, well-conducted MR studies can complement findings from traditional epidemiological studies and randomized controlled trials, collectively contributing to a more solid evidence base for public health policies and prioritization of clinical trial study for communicable and non-communicable diseases [9, 10].