Functional role of post-translational modifications of Sp1 in tumorigenesis

• Published in: Journal of biomedical science Vol. 19; no. 1; p. 94
• Main Authors: Chang, Wen-Chang, Hung, Jan-Jong
• Format: Journal Article
• Language: English
• Published: London BioMed Central 14.11.2012; BioMed Central Ltd; BMC
• Subjects: Apoptosis; Apoptosis - genetics; Biomedical and Life Sciences; Biomedicine; Breast cancer; Cancer; Care and treatment; Cell Differentiation - genetics; Cell Proliferation; Cell Transformation, Neoplastic - genetics; Cell Transformation, Neoplastic - metabolism; DNA-ligand interactions; Gene expression; Gene Expression Regulation, Neoplastic; Genes; Genetic aspects; Humans; Immunoglobulins - genetics; Immunoglobulins - metabolism; Kinases; Methylation; Pancreatic cancer; Protein Processing, Post-Translational - genetics; Proteins; Review; Transcription, Genetic; Tumors; Ubiquitin; Arsenic Trioxide; Ataxia Telangiectasia Mutate; Betulinic Acid; RECK Gene Expression; Tolfenamic Acid
• ISSN: 1423-0127; 1021-7770; 1423-0127
• DOI: 10.1186/1423-0127-19-94

Specific protein 1 (Sp1), the first transcription factor to be isolated, regulates the expression of numerous genes involved in cell proliferation, apoptosis, and differentiation. Recent studies found that an increase in Sp1 transcriptional activity is associated with the tumorigenesis. Moreover, post-translational modifications of Sp1, including glycosylation, phosphorylation, acetylation, sumoylation, ubiquitination, and methylation, regulate Sp1 transcriptional activity and modulate target gene expression by affecting its DNA binding activity, transactivation activity, or protein level. In addition, recent studies have investigated several compounds with anti-cancer activity that could inhibit Sp1 transcriptional activity. In this review, we describe the effect of various post-translational modifications on Sp1 transcriptional activity and discuss compounds that inhibit the activity of Sp1.