Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia

• Published in: Nature genetics Vol. 44; no. 12; pp. 1330 - 1335
• Main Authors: Lan, Qing, Hsiung, Chao A, Matsuo, Keitaro, Seow, Adeline, Wang, Zhaoming, Hosgood, H Dean, Chen, Kexin, Wang, Jiu-Cun, Chatterjee, Nilanjan, Hu, Wei, Wong, Maria Pik, Zheng, Wei, Caporaso, Neil, Park, Jae Yong, Kim, Yeul Hong, Kim, Young Tae, Burdett, Laurie, Yuenger, Jeffrey, Chang, I-Shou, Mitsudomi, Tetsuya, Chang, Gee-Chen, Bassig, Bryan A, Wei, Fusheng, Wu, Chen, An, She-Juan, Qian, Biyun, Lee, Victor Ho Fun, Lu, Daru, Liu, Jianjun, Jeon, Hyo-Sung, Sung, Jae Sook, Kim, Jin Hee, Tsai, Ying-Huang, Jung, Yoo Jin, Guo, Huan, Hu, Zhibin, Hutchinson, Amy, Klein, Robert, Chung, Charles C, Oh, In-Jae, Chen, Kuan-Yu, He, Xingzhou, Wu, Wei, Huang, Ming-Shyan, Zheng, Hong, Wang, Junwen, Zhao, Xueying, Li, Yuqing, Choi, Jin Eun, Park, Kyong Hwa, Shu, Xiao-Ou, Chen, Yuh-Min, Liu, Li, Kang, Chang Hyun, Hu, Lingmin, Chen, Chung-Hsing, Pao, William, Kim, Young-Chul, Yang, Tsung-Ying, Xu, Jun, Guan, Peng, Tan, Wen, Wang, Chih-Liang, Li, Haixin, Sihoe, Alan Dart Loon, Zhao, Zhenhong, Chen, Ying, Choi, Yi Young, Hung, Jen-Yu, Kim, Jun Suk, Cai, Qiuyin, Park, In Kyu, Xu, Ping, Dong, Jing, Kim, Christopher, He, Qincheng, Perng, Reury-Perng, Kohno, Takashi, Vermeulen, Roel, Wu, Junjie, Lim, Wei-Yen, Chen, Kun-Chieh, Chow, Wong-Ho, Ji, Bu-Tian, Chan, John K C, Li, Yao-Jen, Yokota, Jun, Li, Jihua, Chen, Hongyan, Xiang, Yong-Bing, Yu, Chong-Jen, Kunitoh, Hideo, Wu, Guoping, Lo, Yen-Li, Shiraishi, Kouya, Lin, Hsien-Chih, Wu, Yi-Long, Yang, Pan-Chyr, Zhou, Baosen, Shin, Min-Ho
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.12.2012; Nature Publishing Group
• Subjects: 631/208/205/2138; 692/699/67/1612; Adenocarcinoma - genetics; Adenocarcinoma of Lung; Adult; Aged; Agriculture; Animal Genetics and Genomics; Asian People - genetics; Biological and medical sciences; Biomedicine; Cancer Research; Carcinoma, Squamous Cell - genetics; Chromosomes; Chromosomes, Human, Pair 10 - genetics; Chromosomes, Human, Pair 15 - genetics; Chromosomes, Human, Pair 17; Chromosomes, Human, Pair 5 - genetics; Chromosomes, Human, Pair 6 - genetics; Confidence intervals; Disease susceptibility; Epidemiology; Female; Fundamental and applied biological sciences. Psychology; Gene Function; Genetic aspects; Genetic Loci; Genetic Predisposition to Disease; Genetic variance; Genetics of eukaryotes. Biological and molecular evolution; Genome-Wide Association Study; Genomes; Health aspects; Human Genetics; Humans; letter; Lung cancer; Lung Neoplasms - genetics; Medical sciences; Middle Aged; Physiological aspects; Pneumology; Polymorphism, Single Nucleotide; Single nucleotide polymorphisms; Smoking; Studies; Tobacco smoke; Tumors of the respiratory system and mediastinum; Women; Asia; Singapore; Taiwan; Lung disease; Respiratory disease; Lung cancer; Bronchus disease; Identification; Malignant tumor; Locus; Cancer
• ISSN: 1061-4036; 1546-1718; 1546-1718
• DOI: 10.1038/ng.2456

Qing Lan and colleagues report the results of a genome-wide association study of lung cancer in never-smoking women from Asia. They identify three new susceptibility loci and confirm three other previously reported associations. To identify common genetic variants that contribute to lung cancer susceptibility, we conducted a multistage genome-wide association study of lung cancer in Asian women who never smoked. We scanned 5,510 never-smoking female lung cancer cases and 4,544 controls drawn from 14 studies from mainland China, South Korea, Japan, Singapore, Taiwan and Hong Kong. We genotyped the most promising variants (associated at P < 5 × 10 −6 ) in an additional 1,099 cases and 2,913 controls. We identified three new susceptibility loci at 10q25.2 (rs7086803, P = 3.54 × 10 −18 ), 6q22.2 (rs9387478, P = 4.14 × 10 −10 ) and 6p21.32 (rs2395185, P = 9.51 × 10 −9 ). We also confirmed associations reported for loci at 5p15.33 and 3q28 and a recently reported finding at 17q24.3. We observed no evidence of association for lung cancer at 15q25 in never-smoking women in Asia, providing strong evidence that this locus is not associated with lung cancer independent of smoking.