The ups and downs of miR-205: Identifying the roles of miR-205 in mammary gland development and breast cancer

• Published in: RNA biology Vol. 7; no. 3; pp. 300 - 304
• Main Authors: Greene, Stephanie B., Herschkowitz, Jason I., Rosen, Jeffrey M.
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 01.05.2010
• Subjects: Animals; Binding; Biology; Bioscience; breast neoplasms; Breast Neoplasms - genetics; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Calcium; Cancer; Carcinoma - genetics; Carcinoma - metabolism; Carcinoma - pathology; Cell; Cycle; Female; Gene Expression Regulation, Developmental; Humans; Landes; mammary development; mammary glands; Mammary Glands, Human - embryology; Mammary Glands, Human - growth & development; Mammary Glands, Human - metabolism; metastasis; Mice; MicroRNAs - genetics; MicroRNAs - metabolism; MicroRNAs - physiology; Models, Biological; oncogenes; Organogenesis; Organogenesis - genetics; Proteins; stem cells
• ISSN: 1547-6286; 1555-8584; 1555-8584
• DOI: 10.4161/rna.7.3.11837

Recent studies have demonstrated that miR-205 has a role in both normal development and cancer, however conflicting reports on its function illustrate the complexity of its regulation and targets. Additionally, miR-205 was found to be highly expressed in stem cell-enriched populations from the mouse mammary gland, and thus may play a function in normal mammary stem cell maintenance. The role that miR-205 plays in tumor formation and metastasis is likely context-dependent as reports have indicated that it may function as either a tumor suppressor or an oncogene. The role that miR-205 plays in directing stem cell fate is still unknown.