FSI simulation of CSF hydrodynamic changes in a large population of non-communicating hydrocephalus patients during treatment process with regard to their clinical symptoms

• Published in: PloS one Vol. 13; no. 4; p. e0196216
• Main Author: Gholampour, Seifollah
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 30.04.2018; Public Library of Science (PLoS)
• Subjects: Analysis; Biology and Life Sciences; Brain research; Care and treatment; Cerebrospinal fluid; Communication; Computational fluid dynamics; Computer and Information Sciences; Computer simulation; Correlation; Experimental methods; Flow velocity; Fluid dynamics; Fluid-structure interaction; Headache; Health aspects; Hydrocephalus; Interaction models; Laminar flow; Medical imaging; Medical research; Medicine and Health Sciences; Methods; Neurosurgery; NMR; Nuclear magnetic resonance; Parameter sensitivity; Patients; Phase lag; Physical Sciences; Physiology; Pressure; Research and Analysis Methods; Research methodology; Simulation; Three dimensional models; Iran
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0196216

3D fluid-structure interaction modelling was utilized for simulation of 13 normal subjects, 11 non-communicating hydrocephalus (NCH) patients at pre-treatment phase, and 3 patients at five post-treatment phases. Evaluation of ventricles volume and maximum CSF pressure (before shunting) following results validation indicated that these parameters were the most proper hydrodynamic indices and the NCH type doesn't have any significant effect on changes in two indices. The results confirmed an appropriate correlation between these indices although the correlation decreased slightly after the occurrence of disease. NCH raises the intensity of vortex and pulsatility (2.4 times) of CSF flow while the flow remains laminar. On day 18 after shunting, the CSF pressure decreased 81.0% and all clinical symptoms of patients vanished except for headache. Continuing this investigation during the treatment process showed that maximum CSF pressure is the most sensitive parameter to patients' clinical symptoms. Maximum CSF pressure has decreased proportional to the level of decrease in clinical symptoms and has returned close to the pressure range in normal subjects faster than other parameters and simultaneous with disappearance of patients' clinical symptoms (from day 81 after shunting). However, phase lag between flow rate and pressure gradient functions and the degree of CSF pulsatility haven't returned to normal subjects' conditions even 981 days after shunting and NCH has also caused a permanent volume change (of 20.1%) in ventricles. Therefore, patients have experienced a new healthy state in new hydrodynamic conditions after shunting and healing. Increase in patients' intracranial compliance was predicted with a more accurate non-invasive method than previous experimental methods up to more than 981 days after shunting. The changes in hydrodynamic parameters along with clinical reports of patients can help to gain more insight into the pathophysiology of NCH patients.