Neural Correlates of Sexual Cue Reactivity in Individuals with and without Compulsive Sexual Behaviours

• Published in: PloS one Vol. 9; no. 7; p. e102419
• Main Authors: Voon, Valerie, Mole, Thomas B., Banca, Paula, Porter, Laura, Morris, Laurel, Mitchell, Simon, Lapa, Tatyana R., Karr, Judy, Harrison, Neil A., Potenza, Marc N., Irvine, Michael
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 11.07.2014; Public Library of Science (PLoS)
• Subjects: Addiction; Addictions; Addictive behaviors; Adult; Alcohol; Amygdala; Amygdala - pathology; Amygdala - physiopathology; Biology and Life Sciences; Brain Mapping; Case-Control Studies; Circuits; Cocaine; Compulsive Behavior - pathology; Compulsive Behavior - physiopathology; Cortex; Cues; Dissociation; Drug abuse; Eroticism; Exposure; Functional magnetic resonance imaging; Gambling; Gender differences; Gyrus Cinguli - pathology; Gyrus Cinguli - physiopathology; Heterosexuality; Humans; Information processing; Magnetic Resonance Imaging; Male; Males; Medicine and Health Sciences; Motivation; Neostriatum; Neural networks; Neurophysiology; Neurosciences; Psychiatry; Psychopharmacology; Reactivity; Reward; Sexual addiction; Sexual Behavior; Studies; Substance abuse treatment; Ventral Striatum - pathology; Ventral Striatum - physiopathology; United Kingdom > UK
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0102419

Although compulsive sexual behaviour (CSB) has been conceptualized as a "behavioural" addiction and common or overlapping neural circuits may govern the processing of natural and drug rewards, little is known regarding the responses to sexually explicit materials in individuals with and without CSB. Here, the processing of cues of varying sexual content was assessed in individuals with and without CSB, focusing on neural regions identified in prior studies of drug-cue reactivity. 19 CSB subjects and 19 healthy volunteers were assessed using functional MRI comparing sexually explicit videos with non-sexual exciting videos. Ratings of sexual desire and liking were obtained. Relative to healthy volunteers, CSB subjects had greater desire but similar liking scores in response to the sexually explicit videos. Exposure to sexually explicit cues in CSB compared to non-CSB subjects was associated with activation of the dorsal anterior cingulate, ventral striatum and amygdala. Functional connectivity of the dorsal anterior cingulate-ventral striatum-amygdala network was associated with subjective sexual desire (but not liking) to a greater degree in CSB relative to non-CSB subjects. The dissociation between desire or wanting and liking is consistent with theories of incentive motivation underlying CSB as in drug addictions. Neural differences in the processing of sexual-cue reactivity were identified in CSB subjects in regions previously implicated in drug-cue reactivity studies. The greater engagement of corticostriatal limbic circuitry in CSB following exposure to sexual cues suggests neural mechanisms underlying CSB and potential biological targets for interventions.