Accuracy and precision of ultrasound shear wave elasticity measurements according to target elasticity and acquisition depth: A phantom study

• Published in: PloS one Vol. 14; no. 7; p. e0219621
• Main Authors: Suh, Chong Hyun, Yoon, Hee Mang, Jung, Seung Chai, Choi, Young Jun
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 11.07.2019; Public Library of Science (PLoS)
• Subjects: Accuracy; Acoustics; Biology and Life Sciences; Coefficient of variation; Data analysis; Elastic Modulus; Elastic waves; Elasticity; Elasticity Imaging Techniques - standards; Ghosts; Humans; Liver; Mathematical analysis; Measurement; Medical examination; Medicine; Medicine and Health Sciences; Outliers (statistics); People and places; Phantoms, Imaging; Physical Sciences; Regression analysis; Research and Analysis Methods; Shear; Target acquisition; Testing; Tissues (Anatomy); Ultrasonic imaging; Ultrasonic testing; Ultrasonic Waves; Ultrasonography - standards; Ultrasound; Ultrasound imaging; South Korea; Netherlands; France; Japan; Germany
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0219621

To investigate the accuracy and precision of ultrasound shear wave elasticity measurements as a function of target elasticity and acquisition depth. Using five ultrasound systems (VTQ, VTIQ, EPIQ 5, Aixplorer, and Aplio 500), two operators independently measured shear wave elasticities in two phantoms containing five different target elasticities (8±3, 14±4, 25±6, 45±8, and 80±12 kPa) at depths of 15, 30, 35, and 60 mm. Accuracy was assessed by evaluating measurement errors and the proportions of outliers, while factors affecting accuracy were assessed using logistic regression analysis. Measurement errors were defined as differences between the measured values and 1) the margins of the target elasticity, and 2) the median values of the target elasticity. Outliers were defined as measured values outside the margins of the target elasticity. Precision was assessed by calculating the reproducibility of measurements using the within-subject coefficient of variation (wCV). Mean measurement errors and the proportions of outliers were higher for high than for low target elasticities (p<0.001), but did not differ in relation to acquisition depth, either within an elastography system or across the different systems. Logistic regression analysis showed that target elasticity (p<0.001) significantly affected accuracy, whereas acquisition depth (p>0.05) did not. The wCV for the 80±12 kPa target (31.33%) was significantly higher than that for lower elasticity targets (6.96-10.43 kPa; p<0.001). The wCV did not differ across acquisition depths. The individual elastography systems showed consistent results. Targets with high elasticity showed lower accuracy and lower precision than targets with low elasticity, while acquisition depth did not show consistent patterns in either accuracy or precision.