Development and Validation of a Clinical Scoring System for Predicting Risk of HCC in Asymptomatic Individuals Seropositive for Anti-HCV Antibodies

• Published in: PloS one Vol. 9; no. 5; p. e94760
• Main Authors: Lee, Mei-Hsuan, Lu, Sheng-Nan, Yuan, Yong, Yang, Hwai-I, Jen, Chin-Lan, You, San-Lin, Wang, Li-Yu, L'Italien, Gilbert, Chen, Chien-Jen
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 06.05.2014; Public Library of Science (PLoS)
• Subjects: Adult; Aged; Alanine; Alanine transaminase; Algorithms; Antibodies; Biomarkers; Carcinoma, Hepatocellular - blood; Carcinoma, Hepatocellular - pathology; Carcinoma, Hepatocellular - virology; Case-Control Studies; Cirrhosis; Consultation; Cytokines; Derivation; Epidemiology; Female; Genomics; Hazards; Health care; Health economics; Health risks; Hepatitis; Hepatitis C Antibodies - blood; Hepatitis C virus; Hepatocellular carcinoma; Hepatology; Humans; Identification methods; Infections; Interferon; Liver cancer; Liver cirrhosis; Liver diseases; Liver Neoplasms - blood; Liver Neoplasms - pathology; Liver Neoplasms - virology; Male; Medical imaging; Medicine and health sciences; Middle Aged; Mortality; Patients; Prediction models; Preventive medicine; Propensity Score; Public health; Regression analysis; Regression coefficients; Ribonucleic acid; Risk assessment; Risk factors; Risk groups; RNA; RNA, Viral - blood; Statistical models; Ultrasonic imaging; United States > US; Taiwan
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0094760

The development of a risk assessment tool for long-term hepatocellular carcinoma risk would be helpful in identifying high-risk patients and providing information of clinical consultation. The model derivation and validation cohorts consisted of 975 and 572 anti-HCV seropositives, respectively. The model included age, alanine aminotransferase (ALT), the ratio of aspirate aminotransferase to ALT, serum HCV RNA levels and cirrhosis status and HCV genotype. Two risk prediction models were developed: one was for all-anti-HCV seropositives, and the other was for anti-HCV seropositives with detectable HCV RNA. The Cox's proportional hazards models were utilized to estimate regression coefficients of HCC risk predictors to derive risk scores. The cumulative HCC risks in the validation cohort were estimated by Kaplan-Meier methods. The area under receiver operating curve (AUROC) was used to evaluate the performance of the risk models. All predictors were significantly associated with HCC. The summary risk scores of two models derived from the derivation cohort had predictability of HCC risk in the validation cohort. The summary risk score of the two risk prediction models clearly divided the validation cohort into three groups (p<0.001). The AUROC for predicting 5-year HCC risk in the validation cohort was satisfactory for the two models, with 0.73 and 0.70, respectively. Scoring systems for predicting HCC risk of HCV-infected patients had good validity and discrimination capability, which may triage patients for alternative management strategies.